Ziółko E, Muc-Wierzgoń M
5th Department of Internal Diseases Silesian University School, Bytom, Poland.
Haematologia (Budap). 1995;26(3):147-50.
Endolymphatic injection Oil-Bleo (Nippon Kayaku, Japan) was performed on 24 patients for treatment of residual retroperitoneal malignant lymphoma detected after intravenous chemotherapy. The drug was administered once only in a dosage of 60 mg/30 mg per foot. Serum levels of the drug were monitored. The results were compared with data obtained after routine intravenous infusion of aqueous bleomycin to patients with advanced cervical cancer. The results revealed that bleomycin administered intralymphatically reaches maximum concentration after 15 minutes, and bleomycin after intravenous administration reaches maximum concentration at 36 hours.
对24例患者进行了内淋巴注射油博来霉素（日本日本化药株式会社），以治疗静脉化疗后检测到的残留腹膜后恶性淋巴瘤。药物仅给药一次，剂量为每英尺60毫克/30毫克。监测药物的血清水平。将结果与晚期宫颈癌患者常规静脉输注博来霉素水剂后获得的数据进行比较。结果显示，经淋巴管内给药的博来霉素在15分钟后达到最大浓度，而静脉给药的博来霉素在36小时时达到最大浓度。
