Falabella R, Borrero I, Escobar C
Sección Dermatolgía, Hospital Universitario del Valle, Universidad del Valle, Cali, Colombia.
Med Cutan Ibero Lat Am. 1989;17(3):193-8.
Skin specimens were cultured in vitro in a attempt to reproduce epidermal sheets bearing melanocytes. After exploring different parameters and culture conditions, 16 out of 45 samples yielded pigmented epidermal membranes with melanocytes. This epidermis bearing melanocytes was transplanted to a patient with segmental vitiligo and a satisfactory repigmentation was achieved. The factors contributing to the development of this pigmented in vitro cultured epidermis, and the potential of this technology for treating refractory but stable forms of vitiligo, are discussed.
为了培育出带有黑素细胞的表皮片，对皮肤样本进行了体外培养。在探索了不同参数和培养条件后，45个样本中有16个产生了带有黑素细胞的色素沉着表皮膜。将这种带有黑素细胞的表皮移植到一名节段性白癜风患者身上，实现了令人满意的色素再生。本文讨论了促成这种体外培养色素沉着表皮形成的因素，以及该技术治疗难治性但稳定型白癜风的潜力。
