Enkhmaa Davaasambuu, Warburton Nicole, Javzandulam Badrakh, Uyanga Jadambajav, Khishigsuren Yarinpil, Lodoysamba Sereeter, Enkhtur Shonkuuz, Warburton David
The Lifespan Environmental Pollution Global Impact Center at The Saban Research Institute, Children's Hospital of Los Angeles, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA.
BMC Pregnancy Childbirth. 2014 Apr 23;14:146. doi: 10.1186/1471-2393-14-146.
Air pollution is a major health challenge worldwide and has previously been strongly associated with adverse reproductive health. This study aimed to examine the association between spontaneous abortion and seasonal variation of air pollutants in Ulaanbaatar, Mongolia.
Monthly average O3, SO2, NO2, CO, PM10 and PM2.5 levels were measured at Mongolian Government Air Quality Monitoring stations. The medical records of 1219 women admitted to the hospital due to spontaneous abortion between 2009-2011 were examined retrospectively. Fetal deaths per calendar month from January-December, 2011 were counted and correlated with mean monthly levels of various air pollutants by means of regression analysis.
Regression of ambient pollutants against fetal death as a dose-response toxicity curve revealed very strong dose-response correlations for SO2 r > 0.9 (p < 0.001) while similarly strongly significant correlation coefficients were found for NO2 (r > 0.8), CO (r > 0.9), PM10 (r > 0.9) and PM2.5 (r > 0.8), (p < 0.001), indicating a strong correlation between air pollution and decreased fetal wellbeing.
The present study identified alarmingly strong statistical correlations between ambient air pollutants and spontaneous abortion. Further studies need to be done to examine possible correlations between personal exposure to air pollutants and pregnancy loss.
空气污染是全球主要的健康挑战，此前已被证实与不良生殖健康密切相关。本研究旨在探讨蒙古乌兰巴托自然流产与空气污染物季节变化之间的关联。
在蒙古政府空气质量监测站测量每月平均臭氧（O3）、二氧化硫（SO2）、二氧化氮（NO2）、一氧化碳（CO）、可吸入颗粒物（PM10）和细颗粒物（PM2.5）水平。回顾性研究2009年至2011年间因自然流产入院的1219名妇女的病历。统计2011年1月至12月每个日历月的胎儿死亡数，并通过回归分析将其与各种空气污染物的月平均水平相关联。
以胎儿死亡数为因变量，环境污染物为自变量绘制剂量反应毒性曲线，结果显示二氧化硫（SO2）的剂量反应相关性非常强（r>0.9，p<0.001），二氧化氮（NO2）、一氧化碳（CO）、可吸入颗粒物（PM10）和细颗粒物（PM2.5）的相关系数也同样具有高度统计学意义（r>0.8），（p<0.001），表明空气污染与胎儿健康下降之间存在强烈关联。
本研究发现环境空气污染物与自然流产之间存在惊人的强统计相关性。需要进一步研究以探讨个人暴露于空气污染物与妊娠丢失之间的可能关联。
