神经发育、γ-氨基丁酸（GABA）系统功能障碍与精神分裂症
Neurodevelopment, GABA system dysfunction, and schizophrenia.
作者信息
Schmidt Martin J, Mirnics Karoly
机构信息
Department of Psychiatry, Vanderbilt University, Nashville, TN, USA.
1] Department of Psychiatry, Vanderbilt University, Nashville, TN, USA [2] Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN, USA [3] Department of Psychiatry, University of Szeged, Szeged, Hungary.
出版信息
Neuropsychopharmacology. 2015 Jan;40(1):190-206. doi: 10.1038/npp.2014.95. Epub 2014 Apr 24.
Abstract
The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and Bleuler began documenting their findings. However, large clinical research efforts in recent decades have identified numerous genetic and environmental risk factors for schizophrenia. The combined data strongly support the neurodevelopmental hypothesis of schizophrenia and underscore the importance of the common converging effects of diverse insults. In this review, we discuss the evidence that genetic and environmental risk factors that predispose to schizophrenia disrupt the development and normal functioning of the GABAergic system.
摘要
自克雷佩林和布鲁勒开始记录他们的研究结果以来，精神分裂症的起源一直让临床医生和研究人员感到困惑。然而，近几十年来大量的临床研究工作已经确定了许多精神分裂症的遗传和环境风险因素。综合数据有力地支持了精神分裂症的神经发育假说，并强调了多种损伤共同汇聚效应的重要性。在这篇综述中，我们讨论了易患精神分裂症的遗传和环境风险因素会破坏GABA能系统的发育和正常功能的证据。
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