Malcangio M, Bowery N G
Department of Pharmacology, Queen Mary and Westfield College, London, UK.
Trends Pharmacol Sci. 1996 Dec;17(12):457-62. doi: 10.1016/s0165-6147(96)01013-9.
The importance of the inhibitory neurotransmitter, GABA, within higher centres of the mammalian brain is unquestionable. However, its role within the spinal cord is of equal significance. There have been numerous studies over the past two decades that have established GABA as a neurotransmitter at both post- and presynaptic sites in the cord. Here, Marzia Malcangio and Norman Bowery review the current status of GABA in relation to nociception and skeletal muscle tone, and indicate that its contribution to spinal cord function should not be overlooked.
抑制性神经递质γ-氨基丁酸（GABA）在哺乳动物大脑高级中枢中的重要性是毋庸置疑的。然而，它在脊髓中的作用同样重要。在过去二十年里，有大量研究证实GABA在脊髓的突触后和突触前位点都是一种神经递质。在此，马尔齐亚·马尔坎焦和诺曼·鲍里综述了GABA在痛觉感受和骨骼肌张力方面的研究现状，并指出其对脊髓功能的作用不应被忽视。
