Tanahashi N, Gotoh F, Tomita M, Shinohara T, Terayama Y, Mihara B, Ohta K, Nara M
Department of Neurology, Ashikaga Red Cross Hospital, Japan.
Stroke. 1989 Sep;20(9):1202-7. doi: 10.1161/01.str.20.9.1202.
We measured the rate of erythrocyte aggregation using our whole-blood aggregometer in 80 patients with occlusive cerebrovascular disease during the acute and chronic phases. We compared the data with values for 38 age-matched healthy controls. Mean +/- SD erythrocyte aggregability of the patients during both the acute phase (0.145 +/- 0.21/sec, n = 35) and the chronic phase (0.139 +/- 0.21/sec, n = 45) was higher than that in the controls (0.123 +/- 0.21/sec, n = 38; p less than 0.01). Erythrocyte aggregability was positively correlated with the plasma concentration of globulin and fibrinogen and inversely correlated with the albumin:globulin ratio. However, these correlations did not necessarily exclude the possibility that some unknown substance(s) released from ischemic tissue might enhance erythrocyte aggregability.
我们使用全血凝集仪对80例急性和慢性闭塞性脑血管病患者的红细胞聚集率进行了测量。我们将这些数据与38名年龄匹配的健康对照者的值进行了比较。患者急性期（0.145±0.21/秒，n = 35）和慢性期（0.139±0.21/秒，n = 45）的平均红细胞聚集性±标准差均高于对照组（0.123±0.21/秒，n = 38；p<0.01）。红细胞聚集性与球蛋白和纤维蛋白原的血浆浓度呈正相关，与白蛋白：球蛋白比值呈负相关。然而，这些相关性并不一定排除缺血组织释放的某些未知物质可能增强红细胞聚集性的可能性。
