Lechner H, Walzl M, Walzl B, Kleinert G
Department of Neurology, Karl-Frazens University of Graz.
Ital J Neurol Sci. 1993 Apr;14(3):251-5. doi: 10.1007/BF02335667.
Heparin-induced Extracorporeal LDL < total cholesterol, triglycerides, fibrinogen > Precipitation (H.E.L.P.) was applied in cases of acute thromboembolic stroke within 48 to 96 hours after onset. 42 patients had been randomized for the trial. In Group A 12 patients underwent a single H.E.L.P. application, while remaining 10 patients formed a control group. In group B 10 patients had 10 H.E.L.P. applications, the other 10 patients firmed as controls. Results of group A: 4 days after H.E.L.P. an improvement in the Mathew Scale and in the Mini Mental State Examination could be obtained (p < 0.05 each). 10 days after H.E.L.P. all the tests showed significant changes (p < 0.05 in the Mathew Scale and in the Mini Mental State Examination and p < 0.01 in the Activities-of-Daily-Living Score). Relatet to the controls there appeared a statistically significant difference 4 days after H.E.L.P. in the Mini Mental State Examination and in the Activities-of-Daily-Living Score (p < 0.05 each). At day 10 all the tests showed a difference to the controls (p < 0.05 in the Mathew Scale and p < 0.01 in the other tests). Results of group B 10: One day after 1st H.E.L.P. a statistically significant difference could be observed in all the tests (p < 0.05 in the Mathew Scale and the Mini Mental State Examination and p < 0.01 in the Activities-of-Daily-Living Score). At that time even a difference to the controls became visible (p < 0.05 in the Mathew scale, p < 0.01 in the other tests).(ABSTRACT TRUNCATED AT 250 WORDS)
肝素诱导的体外低密度脂蛋白<总胆固醇、甘油三酯、纤维蛋白原>沉淀法（H.E.L.P.）应用于急性血栓栓塞性中风发病后48至96小时内的病例。42例患者被随机分组进行试验。A组12例患者接受单次H.E.L.P.治疗，其余10例患者组成对照组。B组10例患者接受10次H.E.L.P.治疗，另外10例患者作为对照。A组结果：H.E.L.P.治疗4天后，马修量表和简易精神状态检查有改善（每项p<0.05）。H.E.L.P.治疗10天后，所有测试均显示出显著变化（马修量表和简易精神状态检查中p<0.05，日常生活活动评分中p<0.01）。与对照组相比，H.E.L.P.治疗4天后，简易精神状态检查和日常生活活动评分有统计学显著差异（每项p<0.05）。在第10天，所有测试均显示与对照组有差异（马修量表中p<0.05，其他测试中p<0.01）。B组结果：首次H.E.L.P.治疗1天后，所有测试均观察到统计学显著差异（马修量表和简易精神状态检查中p<0.05，日常生活活动评分中p<0.01）。此时甚至与对照组的差异也可见（马修量表中p<0.05，其他测试中p<0.01）。（摘要截断于250字）
