Donat-Vargas C, Gea A, Sayon-Orea C, Carlos S, Martinez-Gonzalez M A, Bes-Rastrollo M
Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain.
J Epidemiol Community Health. 2014 Sep;68(9):834-41. doi: 10.1136/jech-2013-203752. Epub 2014 Apr 23.
Polychlorinated biphenyls (PCB) are persistent organic pollutants (POP) that are consumed because of their bioaccumulation through the food chain. Recent studies have suggested the implication of POPs in the development of metabolic diseases such as type 2 diabetes and obesity. However, this relationship is not entirely consistent, and has not been investigated in longitudinal studies. The purpose of this study was to prospectively examine the association between dietary intake of PCBs and the incidence of obesity in the Seguimiento Universidad de Navarra (SUN) Project.
Our study included 12 313 participants without obesity at baseline, who were followed-up for a median of 8.1 years. Dietary intakes of PCBs, expressed as WHO toxic equivalents, were assessed at baseline through a 136-item semiquantitative food-frequency questionnaire. The published concentration levels of PCBs measured in samples of food consumed in Spain were used to estimate intakes. Multivariable Cox regression models were fitted to estimate HRs and 95% CI for incident obesity.
During follow-up, we observed 621 incident cases of obesity. After adjustment for total energy intake and additional adjustment for potential confounders, participants in the fifth quintile of PCBs intake were at higher risk of becoming obese (adjusted HR: 1.58; (95% CI 1.21 to 2.06)) compared to those in the first quintile. The linear trend test was statistically significant (p<0.001).
Dietary intake of PCBs as estimated using a food frequency questionnaire was associated with a higher incidence of obesity. Nevertheless, further longitudinal studies are needed to confirm our results.
多氯联苯（PCB）是持久性有机污染物（POP），因其会通过食物链进行生物累积而被摄入。近期研究表明，持久性有机污染物与2型糖尿病和肥胖症等代谢性疾病的发生有关。然而，这种关系并不完全一致，且尚未在纵向研究中进行调查。本研究的目的是在纳瓦拉大学跟踪研究（SUN项目）中前瞻性地研究多氯联苯的饮食摄入量与肥胖症发病率之间的关联。
我们的研究纳入了12313名基线时无肥胖症的参与者，对他们进行了中位时间为8.1年的随访。通过一份包含136个条目的半定量食物频率问卷在基线时评估多氯联苯的饮食摄入量，以世界卫生组织毒性当量表示。使用在西班牙消费的食物样本中测得的多氯联苯公布浓度水平来估计摄入量。采用多变量Cox回归模型来估计肥胖症发病的风险比（HR）和95%置信区间（CI）。
在随访期间，我们观察到621例肥胖症新发病例。在调整总能量摄入量并进一步调整潜在混杂因素后，与第一五分位数组的参与者相比，多氯联苯摄入量处于第五五分位数组的参与者肥胖风险更高（调整后的HR：1.58；（95%CI 1.21至2.06））。线性趋势检验具有统计学意义（p<0.001）。
使用食物频率问卷估计的多氯联苯饮食摄入量与较高的肥胖症发病率相关。然而，需要进一步的纵向研究来证实我们的结果。
