Donat-Vargas Carolina, Gea Alfredo, Sayon-Orea Carmen, de la Fuente-Arrillaga Carmen, Martinez-Gonzalez Miguel Angel, Bes-Rastrollo Maira
From the Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain (C.D.-V., A.G., C.S.-O., C.d.l.F.-A., M.A.M.-G., M.B.-R.); and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain (A.G., C.d.l.F.-A., M.A.M.-G., M.B.-R.).
Hypertension. 2015 Apr;65(4):714-21. doi: 10.1161/HYPERTENSIONAHA.114.04435. Epub 2015 Feb 2.
Polychlorinated biphenyls are persistent organic pollutants that are consumed because of their bioaccumulation through the food chain. Evidence from different sources suggests a positive association between polychlorinated biphenyls exposure and the incidence of hypertension. However, no previous prospective study has investigated this potential relationship in adults. We prospectively assessed the association between dietary intake of polychlorinated biphenyls and the incidence of hypertension in a large cohort. The Seguimiento Universidad de Navarra project is a Spanish cohort of university graduates, most of them health professionals. We included 14521 participants, initially free of hypertension, who were followed-up for a median of 8.3 years. Dietary intake of polychlorinated biphenyls was assessed at baseline through a previously validated 136-item semiquantitative food frequency questionnaire. The published concentration levels of polychlorinated biphenyls measured in samples of food consumed in Spain were used to estimate dietary intake. Multivariable Cox regression models were fitted to estimate hazard ratios and 95% confidence interval for incident hypertension. During follow-up, 1497 incident cases of medically diagnosed hypertension were identified. After adjusting for total energy intake and for potential confounders, participants in the fifth quintile of total polychlorinated biphenyls intake were at higher risk of developing hypertension (adjusted hazard ratio, 1.43 [95% confidence interval, 1.09-1.88; P for trend 0.017]) compared with those in the first quintile. In this Mediterranean cohort, dietary intake of polychlorinated biphenyls, estimated using a food frequency questionnaire, was associated with a higher risk of developing hypertension during follow-up. Nevertheless, further longitudinal studies are needed to confirm our results.
多氯联苯是持久性有机污染物，因其通过食物链的生物累积作用而被摄入。来自不同来源的证据表明，多氯联苯暴露与高血压发病率之间存在正相关。然而，此前尚无前瞻性研究调查成年人中的这种潜在关系。我们前瞻性地评估了一个大型队列中多氯联苯的膳食摄入量与高血压发病率之间的关联。纳瓦拉大学跟踪研究项目是一个西班牙大学毕业生队列，其中大多数是健康专业人员。我们纳入了14521名最初无高血压的参与者，对他们进行了中位数为8.3年的随访。通过一份先前验证过的包含136个条目的半定量食物频率问卷在基线时评估多氯联苯的膳食摄入量。利用西班牙消费的食物样本中测得的多氯联苯公布浓度水平来估计膳食摄入量。采用多变量Cox回归模型来估计新发高血压的风险比和95%置信区间。在随访期间，共确定了1497例经医学诊断的高血压新发病例。在调整了总能量摄入量和潜在混杂因素后，多氯联苯总摄入量处于第五分位数的参与者患高血压的风险高于第一分位数的参与者（调整后的风险比为1.43 [95%置信区间为1.09 - 1.88；趋势检验P值为0.017]）。在这个地中海队列中，使用食物频率问卷估计的多氯联苯膳食摄入量与随访期间患高血压的较高风险相关。尽管如此，仍需要进一步的纵向研究来证实我们的结果。
