Wajman José Roberto, Oliveira Fabricio Ferreira de, Schultz Rodrigo Rizek, Marin Sheilla de Medeiros Correia, Bertolucci Paulo Henrique Ferreira
Departamento de Medicina Comportamental, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo, São Paulo, Brazil.
Arq Neuropsiquiatr. 2014 Apr;72(4):273-7. doi: 10.1590/0004-282x20140002.
Cognitive assessment in advanced stages of Alzheimer's disease (AD) is limited by the imprecision of most instruments.
To determine objective cognitive responses in moderate and severe AD patients by way of the Severe Mini-Mental State Examination (SMMSE), and to correlate performances with Mini-Mental State Examination (MMSE) scores.
Consecutive outpatients in moderate and severe stages of AD (Clinical Dementia Rating 2.0 or 3.0) were evaluated and compared according to MMSE and SMMSE scores.
Overall 400 patients were included, 67.5% females, mean age 76.6±6.7 years-old. There was no significant impact of age or gender over MMSE or SMMSE scores. Mean schooling was 4.4±2.5 years, impacting SMMSE scores (p=0.008). Scores on MMSE and SMMSE were significantly correlated (F-ratio=690.6325, p<0.0001).
The SMMSE is influenced by schooling, but not by age or gender, and is an accurate test for assessment of moderate and severe AD.
阿尔茨海默病（AD）晚期的认知评估受到大多数工具不精确性的限制。
通过严重简易精神状态检查（SMMSE）确定中度和重度AD患者的客观认知反应，并将表现与简易精神状态检查（MMSE）分数相关联。
根据MMSE和SMMSE分数对AD中度和重度阶段（临床痴呆评定量表2.0或3.0）的连续门诊患者进行评估和比较。
共纳入400例患者，女性占67.5%，平均年龄76.6±6.7岁。年龄或性别对MMSE或SMMSE分数无显著影响。平均受教育年限为4.4±2.5年，对SMMSE分数有影响（p=0.008）。MMSE和SMMSE分数显著相关（F值=690.6325，p<0.0001）。
SMMSE受受教育年限影响，但不受年龄或性别的影响，是评估中度和重度AD的准确测试。
