Lehrer Steven, Green Sheryl, Rosenzweig Kenneth E
Department of Radiation Oncology, Mount Sinai School of Medicine , New York, New York.
J Caffeine Res. 2013 Mar;3(1):38-40. doi: 10.1089/jcr.2013.0001.
There has been some speculation that caffeine consumption may affect breast cancer. Most case-control studies have not documented evidence of a caffeine-breast cancer incidence link; however, there has been very little analysis of the possible effects of caffeine consumption on breast cancer survival.
We examined overall a 20-year survival of 96 women treated for breast cancer between 1990 and 1994. As part of their health history, these women were asked about coffee drinking.
Fifty-three women drank one cup a day (79.2% survival), 22 women had two cups a day (72.7% survival), and 21 women drank three or more cups a day (42.9% survival). The effect of coffee consumption on survival was significant (=0.006, the log rank test). To exclude the effects of lymph node involvement, age at diagnosis, and smoking history, Cox regression was performed. The effect of coffee was significant (=0.001), independent of the effects of lymph node involvement (=0.012) and age at diagnosis (=0.014), and unrelated to a smoking history (=0.721).
Fatigued breast cancer survivors have an abnormal proinflammatory cytokine activity, an average of 5 years after diagnosis, as well as significant serum cortisol derangements compared to other survivors. One possible interpretation of our results suggests that there is an abnormal hypothalamic-pituitary-adrenal axis functioning in breast cancer patients with persistent fatigue, who might be using coffee to self-medicate. In other words, coffee consumption in the present study might be a surrogate marker for fatigue. Because of the paucity of data regarding caffeine intake, poor sleep, fatigue, and breast cancer survival, further studies could be worthwhile.
一直有一些推测认为摄入咖啡因可能会影响乳腺癌。大多数病例对照研究尚未记录到咖啡因与乳腺癌发病率之间存在关联的证据；然而，对于摄入咖啡因对乳腺癌患者生存率可能产生的影响，几乎没有进行过分析。
我们对1990年至1994年间接受乳腺癌治疗的96名女性的20年生存率进行了全面研究。作为她们健康史的一部分，这些女性被问及咖啡饮用情况。
53名女性每天喝一杯咖啡（生存率为79.2%），22名女性每天喝两杯咖啡（生存率为72.7%），21名女性每天喝三杯或更多杯咖啡（生存率为42.9%）。咖啡摄入量对生存率的影响具有显著性（对数秩检验，P = 0.006）。为排除淋巴结受累情况、诊断时年龄和吸烟史的影响，进行了Cox回归分析。咖啡的影响具有显著性（P = 0.001），独立于淋巴结受累情况（P = 0.012）和诊断时年龄（P = 0.014）的影响，且与吸烟史无关（P = 0.721）。
与其他幸存者相比，疲劳的乳腺癌幸存者在诊断后平均5年时具有异常的促炎细胞因子活性，以及显著的血清皮质醇紊乱。对我们结果的一种可能解释是，持续疲劳的乳腺癌患者存在下丘脑 - 垂体 - 肾上腺轴功能异常，他们可能在用咖啡进行自我治疗。换句话说，本研究中的咖啡消费可能是疲劳的一个替代指标。鉴于关于咖啡因摄入、睡眠不佳、疲劳和乳腺癌生存率的数据匮乏，进一步的研究可能是有价值的。
