肾酶，一种新型分泌酶：其在高血压性缺血性心血管疾病中的作用。
Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases.
作者信息
Li Xiaogang, Huang Ruixia, Xie Zijian, Lin Mingyuan, Liang Zhongshu, Yang Yan, Jiang Weihong
机构信息
Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China (mainland).
出版信息
Med Sci Monit. 2014 Apr 25;20:688-92. doi: 10.12659/MSM.890261.
Abstract
Abstract Renalase, a novel amine oxidase, is mainly expressed in the kidney, heart, and skeletal muscle. It has been known to degrade circulating catecholamines and plays a crucial role in human diseases. Recent studies have demonstrated its structure, unique bioactivities, function, and the gene polymorphisms in human diseases. In this review, we summarize the effects of renalase on hypertension, myocardial ischemia, acute kidney injury (AKI), ischemic stroke, cardiac dysfunction, organ transplantation, and diabetes mellitus reported in numerous studies.
摘要
摘要 肾酶是一种新型胺氧化酶，主要在肾脏、心脏和骨骼肌中表达。已知它可降解循环中的儿茶酚胺，并在人类疾病中起关键作用。最近的研究已经证实了其结构、独特的生物活性、功能以及在人类疾病中的基因多态性。在本综述中，我们总结了众多研究报道的肾酶对高血压、心肌缺血、急性肾损伤（AKI）、缺血性中风、心脏功能障碍、器官移植和糖尿病的影响。
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