Martynowicz Helena, Wieckiewicz Mieszko, Poreba Rafal, Wojakowska Anna, Smardz Joanna, Januszewska Lidia, Markiewicz-Gorka Iwona, Mazur Grzegorz, Pawlas Krystyna, Gac Pawel
Department of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Department of Experimental Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland.
J Clin Med. 2019 Dec 19;9(1):16. doi: 10.3390/jcm9010016.
Renalase, a novel amine oxidase, is involved in the development of hypertension. Sleep bruxism (SB) is a sleep-related behavior characterized by rhythmic or non-rhythmic activity of the masticatory muscles, which leads to the mechanical wear of teeth, pain in the masticatory muscles, and disturbed sleep. Recent studies indicate that SB plays a role in increased blood pressure. Therefore, this study aimed to determine the relationship between sleep bruxism intensity and renalase concentration, which may help in the future to elucidate the pathogenesis of hypertension and other cardiovascular disorders.
SB was evaluated in 87 adult patients using single-night diagnostic polysomnography with video and audio recordings, and the episodes of bruxism were scored according to the standards of the American Academy of Sleep Medicine. The levels of serum renalase were measured in the patients using enzyme-linked immunosorbent assay kits.
SB (Bruxism Episode Index (BEI) ≥2) was diagnosed in 54% (n = 47) of the studied population, and the mean concentration of renalase was found to be decreased in the hypertensive group compared with the normotensive group (133.33 ± 160.71 vs 219.23 ± 220.58, = 0.047). In addition, a linear negative correlation was observed between the renalase concentration and the body mass index (BMI) in the SB group (r = 0.38, < 0.05) but not in controls. Thus, higher BEI and higher BMI were identified as factors independently associated with the lower concentration of renalase, but only in the group of patients which had a blood renalase concentration of >212.5 ng/mL.
There exists an association between renalase concentration and SB intensity, and further studies are needed to clarify the role of renalase in the pathogenesis of hypertension and other cardiovascular disorders.
肾酶是一种新型胺氧化酶，参与高血压的发生发展。睡眠磨牙症（SB）是一种与睡眠相关的行为，其特征为咀嚼肌有节律或无节律的活动，可导致牙齿机械磨损、咀嚼肌疼痛及睡眠障碍。近期研究表明，睡眠磨牙症与血压升高有关。因此，本研究旨在确定睡眠磨牙症强度与肾酶浓度之间的关系，这可能有助于未来阐明高血压及其他心血管疾病的发病机制。
采用单夜诊断多导睡眠图及视频和音频记录对87例成年患者的睡眠磨牙症进行评估，并根据美国睡眠医学学会的标准对磨牙症发作进行评分。使用酶联免疫吸附测定试剂盒检测患者血清肾酶水平。
在所研究的人群中，54%（n = 47）被诊断为睡眠磨牙症（磨牙症发作指数（BEI）≥2），与血压正常组相比，高血压组肾酶平均浓度降低（133.33±160.71 vs 219.23±220.58，P = 0.047）。此外，在睡眠磨牙症组中观察到肾酶浓度与体重指数（BMI）呈线性负相关（r = 0.38，P < 0.05），而在对照组中未观察到。因此，较高的BEI和较高的BMI被确定为与肾酶浓度较低独立相关的因素，但仅在血肾酶浓度>212.5 ng/mL的患者组中如此。
肾酶浓度与睡眠磨牙症强度之间存在关联，需要进一步研究以阐明肾酶在高血压及其他心血管疾病发病机制中的作用。
