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Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes.Isl1通过形成细胞类型特异性复合物直接控制发育中的前脑和脊髓中的胆碱能神经元特性。
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Potential Applications of Mitochondrial Therapy with a Focus on Parkinson's Disease and Mitochondrial Transplantation.以帕金森病和线粒体移植为重点的线粒体疗法的潜在应用
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Mitochondria: A Potential Rejuvenation Tool against Aging.线粒体：对抗衰老的潜在复兴工具。
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Mitochondrial Transfer as a Novel Therapeutic Approach in Disease Diagnosis and Treatment.线粒体转移作为一种疾病诊断和治疗的新治疗方法。
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Mitochondrial transplantation as a promising therapy for mitochondrial diseases.线粒体移植作为一种治疗线粒体疾病的有前景的疗法。
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Mitochondrial Transplantation in Mitochondrial Medicine: Current Challenges and Future Perspectives.线粒体移植在线粒体医学中的应用：当前挑战与未来展望。
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Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease.线粒体移植：在肥胖症、糖尿病和非酒精性脂肪性肝病治疗中的机遇与挑战。
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Energy, Entropy and Quantum Tunneling of Protons and Electrons in Brain Mitochondria: Relation to Mitochondrial Impairment in Aging-Related Human Brain Diseases and Therapeutic Measures.脑线粒体中质子和电子的能量、熵与量子隧穿：与衰老相关的人脑疾病中线粒体损伤及治疗措施的关系
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Mitochondrial DNA Replacement Techniques to Prevent Human Mitochondrial Diseases.线粒体 DNA 替换技术预防人类线粒体疾病。
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本文引用的文献

1
Medicine. Mitochondrial replacement, evolution, and the clinic.医学。线粒体替代、进化与临床。
Science. 2013 Sep 20;341(6152):1345-6. doi: 10.1126/science.1237146.
2
Towards germline gene therapy of inherited mitochondrial diseases.遗传性线粒体疾病的种系基因治疗。
Nature. 2013 Jan 31;493(7434):627-31. doi: 10.1038/nature11647. Epub 2012 Oct 24.
3
Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck.快速的线粒体 DNA 分离发生在灵长类动物胚胎的早期，早于体细和生殖系瓶颈。
Cell Rep. 2012 May 31;1(5):506-15. doi: 10.1016/j.celrep.2012.03.011.
4
Monogenic mitochondrial disorders.单基因线粒体疾病
N Engl J Med. 2012 Mar 22;366(12):1132-41. doi: 10.1056/NEJMra1012478.
5
Mitochondrial haplotype does not influence sperm motility in a UK population of men.线粒体单倍型不会影响英国男性人群的精子活力。
Hum Reprod. 2012 Mar;27(3):641-51. doi: 10.1093/humrep/der438. Epub 2012 Jan 2.
6
Oestrogens ameliorate mitochondrial dysfunction in Leber's hereditary optic neuropathy.雌激素改善 Leber 遗传性视神经病变中的线粒体功能障碍。
Brain. 2011 Jan;134(Pt 1):220-34. doi: 10.1093/brain/awq276. Epub 2010 Oct 13.
7
Xenomitochondrial mice: investigation into mitochondrial compensatory mechanisms.异种线粒体小鼠：线粒体补偿机制的研究。
Mitochondrion. 2011 Jan;11(1):33-9. doi: 10.1016/j.mito.2010.07.003. Epub 2010 Jul 16.
8
Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease.将原核转移到人类胚胎中，以防止线粒体 DNA 疾病的传播。
Nature. 2010 May 6;465(7294):82-5. doi: 10.1038/nature08958. Epub 2010 Apr 14.
9
Mitochondrial gene replacement in primate offspring and embryonic stem cells.灵长类动物后代及胚胎干细胞中的线粒体基因替换
Nature. 2009 Sep 17;461(7262):367-72. doi: 10.1038/nature08368. Epub 2009 Aug 26.
10
Inherited mitochondrial optic neuropathies.遗传性线粒体视神经病变
J Med Genet. 2009 Mar;46(3):145-58. doi: 10.1136/jmg.2007.054270. Epub 2008 Nov 10.

The challenges of mitochondrial replacement.

作者信息

Chinnery Patrick F, Craven Lyndsey, Mitalipov Shoukhrat, Stewart James B, Herbert Mary, Turnbull Douglass M

机构信息

Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, United Kingdom.

Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.

出版信息

PLoS Genet. 2014 Apr 24;10(4):e1004315. doi: 10.1371/journal.pgen.1004315. eCollection 2014 Apr.

DOI:10.1371/journal.pgen.1004315
PMID:24762741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3998882/
Abstract
摘要