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阿尔茨海默病中的功能残疾:痴呆症残疾评估量表土耳其语版本的验证研究。

Functional disability in Alzheimer disease: a validation study of the Turkish version of the disability assessment for dementia scale.

作者信息

Tozlu Mukaddes, Cankurtaran Mustafa, Yavuz Burcu Balam, Cankurtaran Eylem Sahin, Kutluer Ibrahim, Erkek Burcu Manisalı, Halil Meltem, Ulger Zekeriya, Cosgun Erdal, Ariogul Servet

机构信息

Department of Internal Medicine, Division of Geriatric Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Department of Internal Medicine, Division of Geriatric Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey

出版信息

J Geriatr Psychiatry Neurol. 2014 Dec;27(4):237-46. doi: 10.1177/0891988714532014. Epub 2014 Apr 24.

DOI:10.1177/0891988714532014
PMID:24763071
Abstract

This study aimed to determine the reliability and validity of the Turkish version of Disability Assessment for Dementia (DAD) scale in the Turkish elderly population with Alzheimer disease (AD). The DAD scale was administered to the primary caregivers of 157 patients (age 77.7 ± 6.8 years) with AD. The Turkish version of the DAD scale showed high internal consistency (Cronbach α = .942), excellent test-retest, and interrater reliability (intraclass correlation coefficient [ICC] = 0.996 and ICC = 0.994, respectively). The DAD scale was significantly correlated with activities of daily living (ADL; Modified Older Americans Research Survey ADL) and instrumental activities of daily living (IADL; Lawton and Brody IADL) scales (r = .89, P < .001 and r = .90, P < .001). Disability Assessment for Dementia had a high negative correlation with the Global Deterioration Scale (GDS; r = -.880, P < .001). Post hoc comparisons with Tukey test showed significant differences in the mean DAD scores in different GDS stages. Construct validity was estimated using total score correlation analyses between the standardized Mini-Mental State Examination (MMSE) and the DAD scale. Results revealed high and significant correlation between MMSE score and DAD scale (r = .812, P < .001). The results of multivariate analysis showed that DAD score was not correlated with gender, education, and age. The DAD total score was affected mostly by GDS, MMSE, and duration of the disease. Turkish version of the DAD scale was found to be a reliable and valid instrument to assess functional disability in Turkish elderly patients with AD. This scale assists caregivers and physicians to decide for proper interventions.

摘要

本研究旨在确定痴呆症残疾评估量表(DAD)土耳其语版本在患有阿尔茨海默病(AD)的土耳其老年人群中的信度和效度。对157例AD患者(年龄77.7±6.8岁)的主要照顾者施测DAD量表。DAD量表土耳其语版本显示出高内部一致性(Cronbach α = 0.942)、出色的重测信度和评分者间信度(组内相关系数[ICC]分别为0.996和0.994)。DAD量表与日常生活活动(ADL;改良版美国老年人研究调查ADL)量表及工具性日常生活活动(IADL;Lawton和Brody IADL)量表显著相关(r = 0.89,P < 0.001和r = 0.90,P < 0.001)。痴呆症残疾评估量表与总体衰退量表(GDS;r = -0.880,P < 0.001)呈高度负相关。采用Tukey检验进行事后比较,结果显示不同GDS阶段的DAD量表平均得分存在显著差异。通过标准化简易精神状态检查表(MMSE)与DAD量表之间的总分相关分析来估计结构效度。结果显示MMSE得分与DAD量表之间存在高度显著相关性(r = 0.812,P < 0.001)。多变量分析结果显示,DAD得分与性别、教育程度和年龄无关。DAD总分主要受GDS、MMSE和病程的影响。结果发现,DAD量表土耳其语版本是评估患有AD的土耳其老年患者功能残疾的可靠且有效的工具。该量表有助于照顾者和医生决定采取适当的干预措施。

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