Martorana Adriana, Bulati Matteo, Buffa Silvio, Pellicanò Mariavaleria, Caruso Calogero, Candore Giuseppina, Colonna-Romano Giuseppina
Immunosenescence Unit, Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, corso Tukory 211, 90134, Palermo, Italy.
Immunosenescence Unit, Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, corso Tukory 211, 90134, Palermo, Italy ; Department of Internal Medicine II, Center for Medical Research, Tübingen Aging and Tumor Immunology Group, University of Tübingen, Waldhörnlestraße 22, 72072, Tübingen, Germany.
Longev Healthspan. 2012 Nov 1;1:8. doi: 10.1186/2046-2395-1-8. eCollection 2012.
Ageing impacts negatively on the development of the immune system and its ability to fight pathogens. Progressive changes in the T-cell and B-cell systems over the lifespan of individuals have a major impact on the capacity to respond to immune challenges. The cumulative age-associated changes in immune competence are termed immunosenescence that is characterized by changes where adaptive immunity deteriorates, while innate immunity is largely conserved or even upregulated with age. On the other hand, ageing is also characterized by "inflamm-ageing", a term coined to explain the inflammation commonly present in many age-associated diseases. It is believed that immune inflammatory processes are relevant in Alzheimer's disease, the most common cause of dementia in older people. In the present paper we review data focusing on changes of some immunoinflammatory parameters observed in patients affected by Alzheimer's disease.
衰老对免疫系统的发育及其对抗病原体的能力产生负面影响。在个体的生命周期中，T细胞和B细胞系统的渐进性变化对免疫挑战的反应能力有重大影响。与年龄相关的免疫能力累积变化被称为免疫衰老，其特征是适应性免疫功能衰退，而固有免疫在很大程度上得以保留，甚至随年龄增长而上调。另一方面，衰老的特征还包括“炎症衰老”，这一术语用于解释许多与年龄相关疾病中常见的炎症。人们认为免疫炎症过程与阿尔茨海默病相关，阿尔茨海默病是老年人痴呆最常见的病因。在本文中，我们回顾了聚焦于阿尔茨海默病患者中观察到的一些免疫炎症参数变化的数据。
