Levy Neil
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, 3010 Australia.
Biol Philos. 2014;29(3):337-355. doi: 10.1007/s10539-014-9434-2. Epub 2014 Feb 23.
Addiction is almost universally held to be characterized by a loss of control over drug-seeking and consuming behavior. But the actions of addicts, even of those who seem to want to abstain from drugs, seem to be guided by reasons. In this paper, I argue that we can explain this fact, consistent with continuing to maintain that addiction involves a loss of control, by understanding addiction as involving an oscillation between conflicting judgments. I argue that the dysfunction of the mesolimbic dopamine system that typifies addictions causes the generation of a mismatch between the top-down model of the world that reflects the judgment that the addict ought to refrain from drugs, and bottom-up input caused by cues predictive of drug availability. This constitutes a powerful pressure toward revising the judgment and thereby attenuating the prediction error. But the new model is not stable, and shifts under the pressure of bottom-up inputs in different contexts; hence the oscillation of all-things-considered judgment. Evidence from social psychology is adduced, to suggest that a similar process may be involved in ordinary cases of weakness of will.
几乎所有人都认为,成瘾的特征是对寻求和使用毒品的行为失去控制。但成瘾者的行为,即使是那些似乎想要戒除毒品的成瘾者的行为,似乎都是受某些理由驱使的。在本文中,我认为,通过将成瘾理解为涉及相互冲突的判断之间的振荡,我们可以解释这一事实,同时继续认为成瘾涉及失去控制。我认为,典型成瘾中脑边缘多巴胺系统的功能失调导致了一种不匹配的产生,即反映成瘾者应该戒除毒品这一判断的自上而下的世界模型,与由预测毒品可得性的线索引起的自下而上的输入之间的不匹配。这构成了一种强大的压力,促使人们修改判断,从而减少预测误差。但新模型并不稳定,会在不同情境下自下而上输入的压力下发生变化;因此就出现了综合考虑后的判断的振荡。文中引用了社会心理学的证据,表明类似的过程可能在普通的意志薄弱案例中也会涉及。