Liu Liping, Xiao Ziwen, Xiao Yanbing, Wang Zhibiao, Li Faqi, Li Maoping, Peng Xiaoqiong
Department of Ultrasound, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Department of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, P.R. China.
Oncol Lett. 2014 May;7(5):1485-1492. doi: 10.3892/ol.2014.1900. Epub 2014 Feb 21.
The aim of the present study was to evaluate the safety and efficiency of an intravenously delivered nano-hydroxyapatite (Nano-HA) solution into a rabbit model () to determine the potential enhancement of high-intensity focused ultrasound (HIFU) for the ablation of hepatocellular carcinoma (HCC) in liver tissue. The present study clearly indicated that the intravenous delivery of large quantities of Nano-HA into the body of the rabbit model over relatively short periods of time may be absorbed by the hepatic reticuloendothelial system. Subsequent HIFU treatment for HCC, as well as intravenous Nano-HA, produced a rapid increase in temperature and an enlargement of the coagulated necrotic area during ablation in the and environments. In addition, it was found that the therapeutic doses of Nano-HA produced mild and transient abnormalities in the normal renal function and hepatic enzymes during the first 24 h following administration. The results of the current study indicated that the combination of Nano-HA and HIFU may provide a safe and effective alternative to conventional surgical procedures.
本研究的目的是评估静脉注射纳米羟基磷灰石（Nano-HA）溶液在兔模型中的安全性和有效性，以确定其对高强度聚焦超声（HIFU）消融肝组织中肝细胞癌（HCC）的潜在增强作用。本研究清楚地表明，在相对较短的时间内将大量Nano-HA静脉注射到兔模型体内，可能会被肝网状内皮系统吸收。随后对HCC进行HIFU治疗以及静脉注射Nano-HA，在[具体环境1]和[具体环境2]环境下消融过程中导致温度迅速升高和凝固性坏死区域扩大。此外，研究发现，在给药后的最初24小时内，治疗剂量的Nano-HA会使正常肾功能和肝酶出现轻微且短暂的异常。当前研究结果表明，Nano-HA与HIFU联合使用可能为传统外科手术提供一种安全有效的替代方案。
