Rosu Cristian, Cohen Sandra, Meunier Caroline, Ouellette Denise, Beauchamp Gilles, Rakovich George
Division of Thoracic Surgery.
Division of Hematology.
Clin Pract. 2011 Apr 1;1(1):e1. doi: 10.4081/cp.2011.e1. eCollection 2011 Mar 29.
Pure red cell aplasia is a rare cause of anemia, caused by an absence of red blood cell precursors in the bone marrow. It is usually a paraneoplastic syndrome, associated most commonly with large-cell granular lymphocyte leukemia but also thymoma. For patients who present both pure red cell aplasia and thymoma, thymectomy leads to an initial remission of the aplasia in 30% of cases. However, sustained remission may require the addition of medications such as corticosteroids, cyclosporine, or cyclophosphamide. We present a case of pure red cell aplasia associated with a thymoma in an otherwise healthy 80 year-old woman.
纯红细胞再生障碍性贫血是一种罕见的贫血病因，由骨髓中缺乏红细胞前体所致。它通常是一种副肿瘤综合征，最常与大颗粒淋巴细胞白血病相关，但也与胸腺瘤有关。对于同时患有纯红细胞再生障碍性贫血和胸腺瘤的患者，胸腺切除术在30%的病例中可使再生障碍性贫血获得初始缓解。然而，持续缓解可能需要加用皮质类固醇、环孢素或环磷酰胺等药物。我们报告一例80岁健康女性患纯红细胞再生障碍性贫血合并胸腺瘤的病例。
