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本文引用的文献

1
Changing epidemiology of invasive pneumococcal disease in Australian children after introduction of a 7-valent pneumococcal conjugate vaccine.7 价肺炎球菌结合疫苗问世后澳大利亚儿童侵袭性肺炎球菌病的流行情况变化。
Med J Aust. 2011 Feb 7;194(3):116-20. doi: 10.5694/j.1326-5377.2011.tb04192.x.
2
PneumococcaL meningitis in french children before and after the introduction of pneumococcal conjugate vaccine.法国儿童在接种肺炎球菌结合疫苗前后的肺炎球菌性脑膜炎。
Pediatr Infect Dis J. 2011 Feb;30(2):168-70. doi: 10.1097/inf.0b013e3181f4cf69.
3
Prevention of pneumococcal disease among infants and children - use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine - recommendations of the Advisory Committee on Immunization Practices (ACIP).预防婴幼儿肺炎球菌病-使用 13 价肺炎球菌结合疫苗和 23 价肺炎球菌多糖疫苗-免疫实践咨询委员会（ACIP）的建议。
MMWR Recomm Rep. 2010 Dec 10;59(RR-11):1-18.
4
Continued control of pneumococcal disease in the UK - the impact of vaccination.英国持续控制肺炎球菌病 - 疫苗接种的影响。
J Med Microbiol. 2011 Jan;60(Pt 1):1-8. doi: 10.1099/jmm.0.020016-0. Epub 2010 Oct 21.
5
A dynamic model of pneumococcal infection in the United States: implications for prevention through vaccination.美国肺炎链球菌感染的动态模型：疫苗接种预防的意义。
Vaccine. 2010 May 7;28(21):3650-60. doi: 10.1016/j.vaccine.2010.03.030. Epub 2010 Mar 30.
6
Invasive pneumococcal disease in children prior to implementation of the conjugate vaccine in the Zurich region, Switzerland.瑞士苏黎世地区实施结合疫苗前儿童侵袭性肺炎球菌病。
Acta Paediatr. 2010 Jul;99(7):1005-10. doi: 10.1111/j.1651-2227.2010.01748.x. Epub 2010 Mar 5.
7
Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines.侵袭性肺炎球菌病负担和欧洲儿童中肺炎链球菌分离株血清型分布：7 价肺炎球菌结合疫苗的影响以及对未来结合疫苗的考虑。
Int J Infect Dis. 2010 Mar;14(3):e197-209. doi: 10.1016/j.ijid.2009.05.010. Epub 2009 Aug 22.
8
Effect of pneumococcal conjugate vaccine on pneumococcal meningitis.肺炎球菌结合疫苗对肺炎球菌性脑膜炎的影响。
N Engl J Med. 2009 Jan 15;360(3):244-56. doi: 10.1056/NEJMoa0800836.
9
Association of serotype of Streptococcus pneumoniae with risk of severe and fatal outcome.肺炎链球菌血清型与严重及致命结局风险的关联。
Pediatr Infect Dis J. 2009 Feb;28(2):118-22. doi: 10.1097/INF.0b013e318187e215.
10
Postlicensure evaluation of the effectiveness of seven valent pneumococcal conjugate vaccine.七价肺炎球菌结合疫苗上市后有效性评估
Pediatr Infect Dis J. 2001 Dec;20(12):1105-7. doi: 10.1097/00006454-200112000-00002.

尽管接种了7价结合疫苗仍发生侵袭性肺炎球菌感染。

Invasive pneumococcal infection despite 7-valent conjugated vaccine.

作者信息

Joye Sebastien, Gao Anja, Kayemba-Kay's Simon, Cotting Jacques, Perez Marie-Hélène

机构信息

Department of Pediatrics, University Hospital of Lausanne (CHUV) , Switzerland.

Pediatric Intensive Care Unit, University Hospital of Lausanne (CHUV) , Switzerland.

出版信息

Clin Pract. 2013 Mar 25;3(1):e11. doi: 10.4081/cp.2013.e11. eCollection 2013 Jan 25.

DOI:10.4081/cp.2013.e11
PMID:24765491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3981225/
Abstract

Despite good cover with 7-valent vaccination, invasive pneumococcal infections may still be misdiagnosed and may lead to lifethreatening situations or death in young children. New serotypes are emerging and, therefore, clinicians must keep a high level of suspicion in young children regardless of their vaccination status. We report three cases of invasive pneumococcal infection due to new serotypes not covered by the 7-valent conjugated vaccine, two of which led children to death.

摘要

尽管7价疫苗提供了良好的防护，但侵袭性肺炎球菌感染仍可能被误诊，并且可能导致幼儿出现危及生命的情况或死亡。新的血清型不断出现，因此，无论幼儿的疫苗接种状况如何，临床医生都必须保持高度怀疑。我们报告了3例由7价结合疫苗未涵盖的新血清型引起的侵袭性肺炎球菌感染病例，其中2例导致儿童死亡。