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在接种过疫苗且免疫功能正常的13个月大儿童中发生的19A血清型脑膜炎：1例PCV13疫苗接种失败病例

serotype 19A meningitis in well-vaccinated immunocompetent 13-month-old child: a case of PCV13 failure.

作者信息

Kayemba-Kay's Simon, Badran Abdul Monem, Lagneaux Cécile, Kovacs Tamas, Heron Anne

机构信息

Paediatrics & Neonatal Medicine Department Victor Jousselin Hospital Dreux France; Unité de Recherche Clinique URC28 Dreux France.

Paediatrics & Neonatal Medicine Department Victor Jousselin Hospital Dreux France.

出版信息

Clin Case Rep. 2016 Sep 22;4(11):1023-1025. doi: 10.1002/ccr3.660. eCollection 2016 Nov.

DOI:10.1002/ccr3.660
PMID:27830065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5093155/
Abstract

We report a 13-month-old immune-competent male child who was diagnosed with pneumococcal serotype 19A meningitis despite having received three PCV13 injections. Clinicians are reminded that bacterial meningitis can still occur, even in correctly vaccinated children. Investigations should include immune system screening along with abdominal ultrasound to exclude asplenia.

摘要

我们报告了一名13个月大的免疫功能正常男童，尽管已接种三针13价肺炎球菌结合疫苗（PCV13），但仍被诊断为19A血清型肺炎球菌脑膜炎。提醒临床医生，即使是接种疫苗正确的儿童仍可能发生细菌性脑膜炎。检查应包括免疫系统筛查以及腹部超声以排除无脾症。

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Pediatr Infect Dis J. 2015 Oct;34(10):e260-3. doi: 10.1097/INF.0000000000000818.
2
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Clin Pract. 2013 Mar 25;3(1):e11. doi: 10.4081/cp.2013.e11. eCollection 2013 Jan 25.
3
Reduction of invasive pneumococcal disease 3 years after the introduction of the 13-valent conjugate vaccine in the Oxfordshire region of England.在英国牛津郡地区引入13价结合疫苗3年后侵袭性肺炎球菌疾病的减少情况。
J Infect Dis. 2014 Oct 1;210(7):1001-11. doi: 10.1093/infdis/jiu213. Epub 2014 Apr 9.
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PLoS One. 2013 Sep 23;8(9):e74906. doi: 10.1371/journal.pone.0074906. eCollection 2013.
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PLoS One. 2013;8(1):e51460. doi: 10.1371/journal.pone.0051460. Epub 2013 Jan 24.
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