法国儿童在接种肺炎球菌结合疫苗前后的肺炎球菌性脑膜炎。
PneumococcaL meningitis in french children before and after the introduction of pneumococcal conjugate vaccine.
机构信息
GPIP (Groupe de Pathologie Infectieuse Pe ´diatrique) de la SFP (Socie ´te ´ Franc ¸aise de Pe ´diatrie), Paris, France.
出版信息
Pediatr Infect Dis J. 2011 Feb;30(2):168-70. doi: 10.1097/inf.0b013e3181f4cf69.
In France, despite a high rate of pneumococcal conjugate vaccine coverage, the number of cases of pneumococcal meningitis in children did not decline significantly between 2001–2002 (n = 264) and 2007–2008 (n = 244). A decline was observed among children < 2 years old (185 [70.1%] to 134 [54.9%] cases; P = 0.0004), but was counterbalanced by an increase among children ≥ 2 years old (79 [29.9%] to 110 [45.1%] cases). Mean age increased significantly, from 2.3 (median 0.8) to 3.8 (median 1.5) years. After pneumococcal conjugate vaccine 7 implementation, a wide diversity of serotypes implicated in pneumococcalmeningitis was observed; serotypes 19A and 7F were the most frequent.
在法国，尽管肺炎球菌结合疫苗的覆盖率很高，但儿童肺炎球菌性脑膜炎的病例数在 2001-2002 年（n=264）和 2007-2008 年（n=244）之间并没有显著下降。在<2 岁的儿童中观察到下降（185[70.1%]例至 134[54.9%]例；P=0.0004），但在≥2 岁的儿童中观察到上升（79[29.9%]例至 110[45.1%]例）。平均年龄显著增加，从 2.3（中位数 0.8）岁增加到 3.8（中位数 1.5）岁。在肺炎球菌结合疫苗 7 实施后，观察到多种与肺炎球菌性脑膜炎有关的血清型；血清型 19A 和 7F 最为常见。
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