Riess Kenneth James, Haykowsky Mark, Lawrance Richard, Tomczak Corey R, Welsh Robert, Lewanczuk Richard, Tymchak Wayne, Haennel Robert G, Gourishankar Sita
a Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB T6G 2G4, Canada.
Appl Physiol Nutr Metab. 2014 May;39(5):566-71. doi: 10.1139/apnm-2013-0449. Epub 2013 Nov 28.
Renal transplant recipients (RTR) have reduced peak aerobic capacity, muscle strength, arterial function and an unfavorable cardiovascular disease risk (CVD) profile. This study compared the effects of 12 weeks of supervised endurance and strength training (EST, n = 16) versus usual care (UC, n = 15) on peak aerobic capicity, cardiovascular and skeletal muscle function, CVD risk profile, and quality of life (QOL) in RTR (55 ± 13 years). Peak aerobic capacity and exercise hemodynamics, arterial compliance, 24-h blood pressure, muscle strength, lean body mass, CVD risk score, and QOL were assessed before and after 12 weeks. The change in peak aerobic capacity (EST: 2.6 ± 3.1 vs. UC: -0.5 ± 2.5 mL/(kg·min)), cardiac output (EST: 1.7 ± 2.6 vs. UC: -0.01 ± 0.8 L/min), leg press (EST: 48.7 ± 34.1 vs. UC: -10.5 ± 37.7 kg) and leg extension strength (EST: 9.5 ± 10.3 vs. UC: 0.65 ± 5.5 kg) improved significantly after EST compared with UC. The overall change in QOL improved significantly after 12 weeks of EST compared with UC. No significant difference was found between groups for lean body mass, arterial compliance, 24-h blood pressure or CVD risk score. Supervised EST is an effective intervention to improve peak exercise aerobic capacity and cardiac output, muscle strength and QOL in clinically stable RTR.
肾移植受者（RTR）的最大有氧能力峰值、肌肉力量、动脉功能降低，且心血管疾病风险（CVD）状况不佳。本研究比较了12周的监督耐力和力量训练（EST，n = 16）与常规护理（UC，n = 15）对55±13岁RTR的最大有氧能力峰值、心血管和骨骼肌功能、CVD风险状况及生活质量（QOL）的影响。在12周前后评估最大有氧能力峰值和运动血流动力学、动脉顺应性、24小时血压、肌肉力量、瘦体重、CVD风险评分及QOL。与UC相比，EST后最大有氧能力峰值的变化（EST：2.6±3.1 vs. UC：-0.5±2.5 mL/（kg·min））、心输出量（EST：1.7±2.6 vs. UC：-0.01±0.8 L/min）、腿举（EST：48.7±34.1 vs. UC：-10.5±37.7 kg）和腿伸展力量（EST：9.5±10.3 vs. UC：0.65±5.5 kg）显著改善。与UC相比，EST 12周后QOL的总体变化显著改善。两组在瘦体重、动脉顺应性、24小时血压或CVD风险评分方面未发现显著差异。监督下的EST是一种有效的干预措施，可改善临床稳定的RTR的运动最大有氧能力峰值和心输出量、肌肉力量及QOL。
