Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Institute of Urology, Capital Medical University, Beijing, China.
World J Urol. 2023 Dec;41(12):3449-3469. doi: 10.1007/s00345-023-04673-9. Epub 2023 Oct 26.
There is uncertainty about the beneficial effects of exercise intervention for kidney transplant recipients. The purpose of our meta-analysis is to estimate the efficacy of exercise intervention in kidney transplant recipients.
A database search according to the PICOS framework was performed for all published randomized, double-blind, placebo-controlled trials (RCTs) about exercise intervention for kidney transplant recipients. The databases involved include PubMed, Embase, and Cochrane Library.
A total of 16 RCTs (involving 827 patients) in compliance with inclusion criteria were included in our study. The results demonstrated that adequate exercise intervention improved statistically in creatinine clearance [mean difference (MD) = - 0.29, 95% confidence interval (CI) - 0.46 to - 0.11, p = 0.001], serum urea (MD = - 21.57, 95% CI - 35.84 to - 7.29, p = 0.003), VO peak (MD = 3.20, 95% CI 1.97-4.43, p < 0.00001), high-density lipoprotein-cholesterol (HDL-C) (MD = 0.21, 95% CI 0.04-0.37, p = 0.01), 60-s sit to stand test (60-STS) (MD = 14.47, 95% CI 8.89-20.04, p < 0.00001), 6-min walk distance (6-MWD) (MD = 91.87, 95% CI 38.34-145.39, p = 0.0008), and 6-min walk test (6-MWT) (MD = 44.08, 95% CI 20.30-67.87, p = 0.0003) of patients after kidney transplantation. No between-groups differences (p > 0.05) were observed for anthropometric characteristics, body composition, serum cytokine levels, and quality of life short form-36 questionnaire (SF-36).
In kidney transplant recipients, appropriate exercise intervention improved renal function, cardiopulmonary function, physical performance.
The PROSPERO registration number is CRD42022357574.
对于接受肾移植的患者，运动干预的有益效果尚不确定。本荟萃分析的目的是评估运动干预对肾移植受者的疗效。
根据 PICOS 框架对所有已发表的关于肾移植受者运动干预的随机、双盲、安慰剂对照试验（RCT）进行数据库检索。所涉及的数据库包括 PubMed、Embase 和 Cochrane Library。
共有 16 项符合纳入标准的 RCT（涉及 827 例患者）纳入本研究。结果表明，适当的运动干预可显著改善肌酐清除率[均数差值（MD）=-0.29，95%置信区间（CI）-0.46 至-0.11，p=0.001]、血清尿素（MD=-21.57，95%CI-35.84 至-7.29，p=0.003）、峰值摄氧量（MD=3.20，95%CI 1.97-4.43，p<0.00001）、高密度脂蛋白胆固醇（HDL-C）（MD=0.21，95%CI 0.04-0.37，p=0.01）、60 秒坐站测试（60-STS）（MD=14.47，95%CI 8.89-20.04，p<0.00001）、6 分钟步行距离（6-MWD）（MD=91.87，95%CI 38.34-145.39，p=0.0008）和 6 分钟步行测试（6-MWT）（MD=44.08，95%CI 20.30-67.87，p=0.0003）。但两组间在人体测量特征、身体成分、血清细胞因子水平和健康调查简表 36 项问卷（SF-36）方面无差异（p>0.05）。
在肾移植受者中，适当的运动干预可改善肾功能、心肺功能和身体机能。
PROSPERO 注册号为 CRD42022357574。
