Park Jee Eun, Lee Jun-Young, Jeon Hong Jin, Han Kyung Ho, Sohn Ji Hoon, Sung Su Jeong, Cho Maeng Je
Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, South Korea; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, South Korea; Department of Neuropsychiatry, Seoul Metropolitan Boramae Medical Center, Seoul, South Korea.
J Affect Disord. 2014 Jun;162:96-101. doi: 10.1016/j.jad.2014.03.012. Epub 2014 Mar 25.
We compared the influence of major mental disorders on suicidality according to age, adjusting for suicide-related correlates.
This study was based on the Korean national epidemiological survey of mental disorders including community-dwelling adults between 18 and 74 years of age (n=6022). Subjects were classified into three age groups; young (18-39), middle-aged (40-59), and late adulthood (60-74). Face-to-face interviews were conducted using the Korean version of the Composite International Diagnostic Interview. According to age groups, the influence of major depressive disorder (MDD), anxiety disorder, and alcohol use disorder on risk for suicidality were investigated by multiple logistic regression models adjusting for sex, years of education, marital status, income, employment, presence of chronic medical illness, and lifetime history of suicide attempt.
After including MDD as a covariate, anxiety disorder remained a risk factor only in the middle-aged group (adjusted OR: 2.83, 95% CI: 1.54-5.22), and alcohol use disorder was a risk factor for suicidality only in the young group (adjusted OR: 2.81, 95% CI: 1.06-7.43). Conversely, MDD was the only mental disorder that significantly increased suicidality in all age groups.
This was a cross-sectional study and did not include subjects over 75 years of age.
This study showed that the contribution of psychiatric disorders to risk for suicidality varied according to age group. Therefore, strategies for suicide prevention should be specifically designed for different age groups.
我们根据年龄比较了主要精神障碍对自杀倾向的影响，并对与自杀相关的因素进行了校正。
本研究基于韩国全国精神障碍流行病学调查，纳入了18至74岁的社区居住成年人（n = 6022）。受试者被分为三个年龄组：青年（18 - 39岁）、中年（40 - 59岁）和老年（60 - 74岁）。使用韩国版的综合国际诊断访谈进行面对面访谈。根据年龄组，通过多因素logistic回归模型，在对性别、受教育年限、婚姻状况、收入、就业、慢性疾病的存在以及自杀未遂的终生史进行校正后，研究重度抑郁症（MDD）、焦虑症和酒精使用障碍对自杀倾向风险的影响。
将MDD作为协变量纳入后，焦虑症仅在中年组中仍是一个风险因素（校正比值比：2.83，95%置信区间：1.54 - 5.22），而酒精使用障碍仅在青年组中是自杀倾向的一个风险因素（校正比值比：2.81，95%置信区间：1.06 - 7.43）。相反，MDD是唯一在所有年龄组中均显著增加自杀倾向的精神障碍。
这是一项横断面研究，未纳入75岁以上的受试者。
本研究表明，精神障碍对自杀倾向风险的影响因年龄组而异。因此，自杀预防策略应针对不同年龄组专门设计。
