Alver Robert C, Chadha Gaganmeet Singh, Blow J Julian
Centre for Gene Regulation & Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Centre for Gene Regulation & Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
DNA Repair (Amst). 2014 Jul;19(100):182-9. doi: 10.1016/j.dnarep.2014.03.012. Epub 2014 Apr 24.
The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a strong selective pressure on the positioning of licensed origins. In light of this, we discuss the complex and disparate phenotypes observed in mouse models and humans patients that arise due to defects in replication licensing proteins.
真核细胞精确且准确地复制其DNA的能力对于维持基因组稳定性至关重要。在此，我们描述了目前对DNA复制起始点获得许可的过程的理解，并回顾了近期的研究工作，这些工作表明复制叉停滞对已获得许可的起始点的定位施加了强大的选择压力。鉴于此，我们讨论了在小鼠模型和人类患者中由于复制许可蛋白缺陷而观察到的复杂且不同的表型。
