Liu Nian, Pan Tao
Department of Chemistry, University of Chicago, Chicago, Ill.
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Ill; Institute of Biophysical Dynamics, University of Chicago, Chicago, Ill.
Transl Res. 2015 Jan;165(1):28-35. doi: 10.1016/j.trsl.2014.04.003. Epub 2014 Apr 8.
Mammalian messenger RNA (mRNA) and long noncoding RNA (lncRNA) contain tens of thousands of posttranscriptional chemical modifications. Among these, the N(6)-methyl-adenosine (m(6)A) modification is the most abundant and can be removed by specific mammalian enzymes. m(6)A modification is recognized by families of RNA binding proteins that affect many aspects of mRNA function. mRNA/lncRNA modification represents another layer of epigenetic regulation of gene expression, analogous to DNA methylation and histone modification.
哺乳动物信使核糖核酸（mRNA）和长链非编码核糖核酸（lncRNA）含有成千上万种转录后化学修饰。其中，N⁶-甲基腺苷（m⁶A）修饰最为丰富，且可被特定的哺乳动物酶去除。m⁶A修饰可被影响mRNA功能多个方面的RNA结合蛋白家族识别。mRNA/lncRNA修饰代表了基因表达表观遗传调控的另一层面，类似于DNA甲基化和组蛋白修饰。
