RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell. 2014 May 8;157(4):845-57. doi: 10.1016/j.cell.2014.04.009. Epub 2014 Apr 24.
Neuronal oscillations have been hypothesized to play an important role in cognition and its ensuing behavior, but evidence that links a specific neuronal oscillation to a discrete cognitive event is largely lacking. We measured neuronal activity in the entorhinal-hippocampal circuit while mice performed a reward-based spatial working memory task. During the memory retention period, a transient burst of high gamma synchronization preceded an animal's correct choice in both prospective planning and retrospective mistake correction, but not an animal's incorrect choice. Optogenetic inhibition of the circuit targeted to the choice point area resulted in a coordinated reduction in both high gamma synchrony and correct execution of a working-memory-guided behavior. These findings suggest that transient high gamma synchrony contributes to the successful execution of spatial working memory. Furthermore, our data are consistent with an association between transient high gamma synchrony and explicit awareness of the working memory content.
神经元振荡被假设在认知及其后续行为中发挥重要作用，但将特定神经元振荡与离散认知事件联系起来的证据在很大程度上仍然缺乏。当老鼠执行基于奖励的空间工作记忆任务时，我们测量了内嗅-海马电路中的神经元活动。在记忆保持期间，在动物的正确选择之前，会出现短暂的高频伽马同步爆发，无论是在预期规划中还是在回顾性错误纠正中，但在动物的错误选择中则不会出现。针对选择点区域的电路进行光遗传抑制会导致高频伽马同步和工作记忆指导行为的正确执行协调减少。这些发现表明，短暂的高频伽马同步有助于成功执行空间工作记忆。此外，我们的数据与高频伽马同步的短暂性和对工作记忆内容的明确意识之间的关联相一致。
