Nakazono Tomoaki, Jun Heechul, Blurton-Jones Mathew, Green Kim N, Igarashi Kei M
Department of Anatomy and Neurobiology, University of California Irvine, United States; Center for the Neurobiology of Learning and Memory, University of California Irvine, United States.
Department of Neurobiology & Behavior, University of California Irvine, United States; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, United States; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, United States.
Neurosci Res. 2018 Apr;129:40-46. doi: 10.1016/j.neures.2018.02.002. Epub 2018 Feb 10.
Gamma oscillations that occur within the entorhinal cortex-hippocampal circuitry play important roles in the formation and retrieval of memory in healthy brains. Recent studies report that gamma oscillations are impaired in the entorhinal-hippocampal circuit of Alzheimer's disease (AD) patients and AD animal models. Here we review the latest advancements in studies of entorhinal-hippocampal gamma oscillations in healthy memory and dementia. This review is especially salient for readers in Alzheimer's research field not familiar with in vivo electrophysiology. Recent studies have begun to show a causal link between gamma oscillations and AD pathology, suggesting that gamma oscillations may even offer a plausible future therapeutic target.
内嗅皮层 - 海马回路中出现的伽马振荡在健康大脑的记忆形成和提取过程中发挥着重要作用。最近的研究报告称，阿尔茨海默病（AD）患者和AD动物模型的内嗅 - 海马回路中的伽马振荡受损。在此，我们综述了关于健康记忆和痴呆症中内嗅 - 海马伽马振荡研究的最新进展。对于阿尔茨海默病研究领域中不熟悉体内电生理学的读者而言，本综述尤为重要。最近的研究已开始揭示伽马振荡与AD病理学之间的因果联系，这表明伽马振荡甚至可能为未来提供一个可行的治疗靶点。
