癌症代谢与表观遗传学中的O-连接N-乙酰葡糖胺信号传导
O-GlcNAc signaling in cancer metabolism and epigenetics.
作者信息
Singh Jay Prakash, Zhang Kaisi, Wu Jing, Yang Xiaoyong
机构信息
Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA; Section of Comparative Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA.
Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA; Section of Comparative Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA; Department of Cellular & Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA.
出版信息
Cancer Lett. 2015 Jan 28;356(2 Pt A):244-50. doi: 10.1016/j.canlet.2014.04.014. Epub 2014 Apr 24.
Abstract
The covalent attachment of β-D-N-acetylglucosamine monosaccharides (O-GlcNAc) to serine/threonine residues of nuclear and cytoplasmic proteins is a major regulatory mechanism in cell physiology. Aberrant O-GlcNAc modification of signaling proteins, metabolic enzymes, and transcriptional and epigenetic regulators has been implicated in cancer. Relentless growth of cancer cells requires metabolic reprogramming that is intertwined with changes in the epigenetic landscape. This review highlights the emerging role of protein O-GlcNAcylation at the interface of cancer metabolism and epigenetics.
摘要
β-D-N-乙酰葡糖胺单糖（O-GlcNAc）与核蛋白和胞质蛋白的丝氨酸/苏氨酸残基的共价连接是细胞生理学中的一种主要调节机制。信号蛋白、代谢酶以及转录和表观遗传调节因子的异常O-GlcNAc修饰与癌症有关。癌细胞的持续生长需要代谢重编程，而这与表观遗传格局的变化相互交织。本综述重点介绍了蛋白质O-GlcNAcylation在癌症代谢与表观遗传学界面的新作用。
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J Biol Chem. 2014 Feb 28;289(9):5986-96. doi: 10.1074/jbc.M113.524140. Epub 2014 Jan 6.
2
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Science. 2013 Dec 6;342(6163):1235-9. doi: 10.1126/science.1243990.
3
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Nat Rev Genet. 2013 Dec;14(12):853-64. doi: 10.1038/nrg3603. Epub 2013 Nov 12.
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6
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Front Endocrinol (Lausanne). 2013 Aug 12;4:99. doi: 10.3389/fendo.2013.00099. eCollection 2013.
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