Kathiravan V, Ravi S, Ashokkumar S
Department of Physics, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
Department of Engg. Physics, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Sep 15;130:116-21. doi: 10.1016/j.saa.2014.03.107. Epub 2014 Apr 13.
Silver nanoparticles have a significant role in the pharmaceutical science. Especially, silver nanoparticles synthesized by the plant extracts lead a significant role in biological activities such as antimicrobial, antioxidant and anticancer. Keeping this in mind, the present work investigation has been taken up with the synthesized silver nanoparticles using the plant extract of Melia dubia and it characterizes by using UV-visible, XRD and SEM-EDS. The effect of the silver nanoparticles on human breast cancer (KB) cell line has been tested. Silver nanoparticles showed remarkable cytotoxicity activity against KB cell line with evidence of high therapeutic index value are the results are discussed.
银纳米颗粒在制药科学中具有重要作用。特别是，由植物提取物合成的银纳米颗粒在抗菌、抗氧化和抗癌等生物活性中发挥着重要作用。鉴于此，本研究采用杜英属植物提取物合成银纳米颗粒，并通过紫外可见光谱、X射线衍射和扫描电子显微镜-能谱分析对其进行表征。测试了银纳米颗粒对人乳腺癌（KB）细胞系的作用。银纳米颗粒对KB细胞系显示出显著的细胞毒性活性，具有高治疗指数值的证据，并对结果进行了讨论。
