自组装药物两亲体中游离喜树碱的连接子决定的药物释放机制
Linker-determined drug release mechanism of free camptothecin from self-assembling drug amphiphiles.
作者信息
Cheetham Andrew G, Ou Yu-Chuan, Zhang Pengcheng, Cui Honggang
机构信息
Department of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology (INBT), The Johns Hopkins University, Baltimore, MD 21218, USA.
出版信息
Chem Commun (Camb). 2014 Jun 7;50(45):6039-42. doi: 10.1039/c3cc49453e. Epub 2014 Apr 28.
Abstract
We report here that the release mechanism of free camptothecin from self-assembling drug amphiphiles can be regulated by use of different linker groups. Our results highlight the significance of the linker group of drug amphiphiles on the drug release efficiency and their consequent in vitro efficacy.
摘要
我们在此报告，通过使用不同的连接基团，可以调节自组装药物两亲物中游离喜树碱的释放机制。我们的结果突出了药物两亲物的连接基团对药物释放效率及其后续体外疗效的重要性。
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