Department of Chemical and Biomolecular Engineering, and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.
Chem Commun (Camb). 2013 May 28;49(43):4968-70. doi: 10.1039/c3cc41896k.
We report here the self-assembly of a rationally designed paclitaxel drug amphiphile into well-defined supramolecular filaments that possess a fixed 41% paclitaxel loading. These filaments can exert effective cytotoxicity against a number of cell lines comparable to that of free paclitaxel.
我们在此报告，一种经过合理设计的紫杉醇药物两亲体能够自组装成具有固定 41%紫杉醇负载量的、结构明确的超分子纤维。这些纤维对多种细胞系的细胞毒性与游离紫杉醇相当，具有有效的细胞毒性。
