通过药物偶联，基因编码肽聚合物的热响应性纳米粒子的自组装。
Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation.
机构信息
Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Box 90281, Durham, NC 27708-0281, USA.
出版信息
Angew Chem Int Ed Engl. 2013 Feb 4;52(6):1683-7. doi: 10.1002/anie.201200899. Epub 2012 Dec 20.
Abstract
Chimeric polypeptides (CPs) that are derived from elastin-like polypeptides (ELPs) can self-assemble to form nanoparticles by site-specific covalent attachment of hydrophobic molecules to one end of the biopolymer backbone. Molecules with a distribution coefficient greater than 1.5 impart sufficient amphiphilicity to drive self-assembly into sub-100 nm nanoparticles.
摘要
嵌合多肽（CPs）来源于弹性蛋白样多肽（ELPs），通过将疏水分子在生物聚合物主链的一端进行特异性共价连接，可以自组装形成纳米颗粒。分配系数大于 1.5 的分子具有足够的两亲性，可以驱动自组装成小于 100nm 的纳米颗粒。
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