新型喜树碱前药自组装纳米胶束，该前药具有氧化还原响应释放机制。
Self-assembling nanomicelles of a novel camptothecin prodrug engineered with a redox-responsive release mechanism.
机构信息
School of Chemical Engineering, Northwest University, Xi'an 710069, China.
出版信息
Chem Commun (Camb). 2011 Aug 14;47(30):8647-9. doi: 10.1039/c1cc12495a. Epub 2011 Jul 1.
PMID:21725532
Abstract
A novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed.
摘要
设计了一种新型两亲性喜树碱前药，该前药可自发排列成纳米胶束，在与肿瘤相关的还原条件下优先释放细胞毒性药物。
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