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Serum growth arrest-specific protein 6 levels are elevated in adult-onset Still's disease.

作者信息

Kim Hyoun-Ah, Nam Jin-Young, Jung Ju-Yang, Bae Chang-Bum, An Jeong-Mi, Jeon Ja-Young, Kim Bong-Sik, Suh Chang-Hee

机构信息

Department of Rheumatology, Ajou University School of Medicine, San 5, Wonchon-dong, Yeongtong-gu, Suwon, 443-721, South Korea.

出版信息

Clin Rheumatol. 2014 Jun;33(6):865-8. doi: 10.1007/s10067-014-2629-8. Epub 2014 Apr 27.

DOI:10.1007/s10067-014-2629-8
PMID:24770797
Abstract

We investigated the growth arrest-specific protein 6 in adult-onset Still's disease. Serums were collected from 52 adult-onset Still's disease patients with follow-up samples of 21 patients. The growth arrest-specific protein 6 levels in adult-onset Still's disease were higher compared to those in the normal controls (25.37±7.71 vs. 19.86±5.01 ng/mL, p<0.001). However, growth arrest-specific protein 6 did not correlate with disease activity. Also, growth arrest-specific protein 6 was not decreased after activity was resolved in the follow-up. The growth arrest-specific protein 6 in adult-onset Still's disease patients were higher than the normal controls. However, growth arrest-specific protein 6 was not correlated with disease activity.

摘要

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本文引用的文献

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Adult Onset Still's Disease and Autoinflammation.成人斯蒂尔病与自身炎症
Int J Inflam. 2012;2012:964751. doi: 10.1155/2012/964751. Epub 2012 Aug 29.
2
Serum growth arrest-specific protein 6 levels are a reliable biomarker of disease activity in systemic lupus erythematosus.血清生长停滞特异性蛋白 6 水平是系统性红斑狼疮疾病活动的可靠生物标志物。
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3
Serum S100A8/A9, but not follistatin-like protein 1 and interleukin 18, may be a useful biomarker of disease activity in adult-onset Still's disease.
血清 S100A8/A9,但不是卵泡抑素样蛋白 1 和白细胞介素 18,可能是成人斯蒂尔病疾病活动的有用生物标志物。
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4
TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus.狼疮中 TAM 受体配体:蛋白 S 而非 Gas6 水平反映系统性红斑狼疮的疾病活动度。
Arthritis Res Ther. 2010;12(4):R146. doi: 10.1186/ar3088. Epub 2010 Jul 16.
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Adult-onset Still disease.成人斯蒂尔病
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Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes.Gas6通过增强内皮细胞、血小板和白细胞之间的相互作用来促进炎症反应。
Blood. 2008 Apr 15;111(8):4096-105. doi: 10.1182/blood-2007-05-089565. Epub 2007 Dec 21.
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TAM receptors are pleiotropic inhibitors of the innate immune response.酪氨酸激酶受体(TAM)是先天性免疫反应的多效性抑制剂。
Cell. 2007 Dec 14;131(6):1124-36. doi: 10.1016/j.cell.2007.10.034.
10
Growth arrest-specific protein 6 plasma concentrations during septic shock.脓毒性休克期间生长停滞特异性蛋白6的血浆浓度
Crit Care. 2007;11(1):R8. doi: 10.1186/cc5158.