Holcroft J W, Vassar M J, Perry C A, Gannaway W L, Kramer G C
University of California, Davis 95616.
Braz J Med Biol Res. 1989;22(2):291-3.
Animal studies with hypertonic solutions suggest that they can achieve resuscitation of hypovolemic shock with extremely small volumes. Such small volume resuscitation might be ideal in the field treatment of injured patients. Our studies to date, with 60 patients entered into a prospective, randomized, placebo-controlled, and double-blind clinical trial, suggest that the use of a 7.5% NaCl/Dextran 70 solution increases blood pressures during transport. The solutions have been safe, and we have encountered no adverse side effects from their use. Survival rates to date favor use of the solutions, but we do not have convincing statistical significance yet in that regard.
对高渗溶液进行的动物研究表明，它们能用极少的容量实现低血容量性休克的复苏。这种小容量复苏在创伤患者的现场治疗中可能是理想的。我们迄今为止的研究纳入了60例患者，进行了一项前瞻性、随机、安慰剂对照、双盲临床试验，结果表明使用7.5%氯化钠/右旋糖酐70溶液可在转运过程中升高血压。这些溶液一直很安全，我们尚未遇到使用它们产生的不良副作用。迄今为止的生存率支持使用这些溶液，但在这方面我们尚未获得令人信服的统计学意义。
