吸烟的艾滋病毒阳性患者面临的独特挑战：艾滋病毒血症、抗逆转录病毒治疗依从性、参与艾滋病毒护理以及并发药物使用。
The unique challenges facing HIV-positive patients who smoke cigarettes: HIV viremia, ART adherence, engagement in HIV care, and concurrent substance use.
作者信息
O'Cleirigh Conall, Valentine Sarah E, Pinkston Megan, Herman Debra, Bedoya C Andres, Gordon Janna R, Safren Steven A
机构信息
Department of Psychiatry, Massachusetts General Hospital, One Bowdoin Square, 7th Floor, Boston, MA, 02114, USA,
出版信息
AIDS Behav. 2015 Jan;19(1):178-85. doi: 10.1007/s10461-014-0762-7.
Evidence suggests that smoking may have negative associations with HIV health outcomes. The smoking rate in our sample of people living with HIV (N = 333) was triple that of the general population (57 v. 19 %). Regression analyses revealed that (smokers v. non-smokers) reported lower medication adherence (unstandardized beta = 9.01) and were more likely to have a detectable viral load (OR = 2.85, 95 % CI [1.53-5.30]). Smokers attended fewer routine medical visits (β = -0.16) and were more likely to report recent hospitalization (OR = 1.89, 95 % CI [0.99, 3.57]). Smokers ranked "health" as less important to their quality of life (β = -0.13) and were more likely to report problematic alcohol (OR = 2.40, 95 % CI [1.35, 4.30]), cocaine (OR = 2.87, 95 % CI [1.48-5.58]), heroin (OR = 4.75, 95 % CI [1.01, 22.30]), or marijuana use (OR = 3.08, 95 % CI [1.76-5.38]). Findings underscore the need for integrated behavioral smoking cessation interventions and routine tobacco screenings in HIV primary care.
有证据表明，吸烟可能与艾滋病毒健康结果存在负面关联。我们的艾滋病毒感染者样本（N = 333）中的吸烟率是普通人群的三倍（57%对19%）。回归分析显示，吸烟者（与不吸烟者相比）报告的药物依从性较低（未标准化β = 9.01），且病毒载量更有可能被检测到（OR = 2.85，95%置信区间[1.53 - 5.30]）。吸烟者的常规医疗就诊次数较少（β = -0.16），且更有可能报告近期住院情况（OR = 1.89，95%置信区间[0.99, 3.57]）。吸烟者将“健康”列为对其生活质量不太重要的因素（β = -0.13），且更有可能报告存在酒精问题（OR = 2.40，95%置信区间[1.35, 4.30]）、可卡因使用问题（OR = 2.87，95%置信区间[1.48 - 5.58]）、海洛因使用问题（OR = 4.75，95%置信区间[1.01, 22.30]）或大麻使用问题（OR = 3.08，95%置信区间[1.76 - 5.38]）。研究结果强调了在艾滋病毒初级护理中开展综合行为戒烟干预和常规烟草筛查的必要性。
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