Peng Hsin-Yi, Lai Chin-Chun, Lin Chih-Chien, Chou Su-Tze
Department of Food and Nutrition, Providence University, No. 200, Section 7, Taiwan Boulevard, Shalu, Taichung 43301, Taiwan.
Department of Cosmetic Science, Providence University, No. 200, Section 7, Taiwan Boulevard, Shalu, Taichung 43301, Taiwan.
ScientificWorldJournal. 2014 Mar 19;2014:213013. doi: 10.1155/2014/213013. eCollection 2014.
The major objective of this study was to estimate the hypopigmentation function of the essential oil from Vetiveria zizanioides (VZ-EO). Our results indicated that VZ-EO exhibits potent lipid peroxidation inhibitory activity to moderate the bleaching of β-carotene and to maintain the cellular glutathione (GSH) levels. VZ-EO can markedly decrease melanin production and tyrosinase activity in α-melanin-stimulating-hormone- (α-MSH-) stimulated B16 cells. The effect of VZ-EO on melanogenesis is achieved by the suppression of cellular tyrosinase expression. The results demonstrated that the activity of VZ-EO on melanogenesis might be the result of its potent antioxidative ability, which was reflected in the decreased cellular oxidant and malondialdehyde (MDA) levels and the recovered activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) in α-MSH-stimulated B16 cells. The most abundant compound in VZ-EO is cedr-8-en-13-ol (12.4%), which has a strong capability to inhibit lipid peroxidation. Therefore, VZ-EO has the potential to become an ingredient in future hypopigmentation drugs, foods, and cosmetics.
本研究的主要目的是评估香根草精油（VZ-EO）的色素减退功能。我们的结果表明，VZ-EO具有强大的脂质过氧化抑制活性，可减轻β-胡萝卜素的漂白并维持细胞内谷胱甘肽（GSH）水平。VZ-EO可显著降低α-促黑素（α-MSH）刺激的B16细胞中的黑色素生成和酪氨酸酶活性。VZ-EO对黑色素生成的影响是通过抑制细胞酪氨酸酶表达来实现的。结果表明，VZ-EO对黑色素生成的活性可能是其强大抗氧化能力的结果，这体现在α-MSH刺激的B16细胞中细胞氧化剂和丙二醛（MDA）水平的降低以及超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPX）和过氧化氢酶（CAT）活性的恢复。VZ-EO中含量最丰富的化合物是雪松-8-烯-13-醇（12.4%），它具有很强的抑制脂质过氧化的能力。因此，VZ-EO有潜力成为未来色素减退药物、食品和化妆品的一种成分。
