线粒体 DNA 拷贝数与头颈部癌症的诊断和预后相关。
Mitochondrial DNA copy number is associated with diagnosis and prognosis of head and neck cancer.
机构信息
Institute of Medicine, Chung Shan Medical University , Taichung , Taiwan .
出版信息
Biomarkers. 2014 Jun;19(4):269-74. doi: 10.3109/1354750X.2014.902101. Epub 2014 Apr 29.
CONTEXT
Mitochondrial DNA (mtDNA) copy number correlates with tumor pathology in some cancers.
OBJECTIVE
To investigate mtDNA copy number in head and neck cancer (HNC).
MATERIALS AND METHODS
mtDNA copy number was determined and compared between HNC patients and malignancy-free controls.
RESULTS
The mtDNA copy number was significantly higher in HNC patients, increased with cancer progression and correlated negatively with patient survival.
DISCUSSION
mtDNA copy number appears to be associated with HNC stage and survival, but confirmation requires similar studies in larger cohorts.
CONCLUSION
Studies to establish the nature of the relationship between mtDNA copy number and HNC are warranted.
背景
线粒体 DNA（mtDNA）拷贝数与某些癌症的肿瘤病理学相关。
目的
研究头颈部癌症（HNC）中的 mtDNA 拷贝数。
材料与方法
测定 HNC 患者和无恶性肿瘤对照者的 mtDNA 拷贝数并进行比较。
结果
HNC 患者的 mtDNA 拷贝数明显较高，随着癌症进展而增加，并与患者生存呈负相关。
讨论
mtDNA 拷贝数似乎与 HNC 分期和生存相关，但需要在更大的队列中进行类似的研究加以证实。
结论
有必要开展研究以确定 mtDNA 拷贝数与 HNC 之间的关系性质。
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