Morikawa T, Chiyoda S, Yamada Y
Rinsho Ketsueki. 1989 May;30(5):702-6.
Chronic adult T-cell leukemia with surface phenotype CD 4+5+8-, Leu 7+ at acute crisis was presented. A 43-year-old female visited our hospital complaining of generalized lymphadenopathy and skin rash in December, 1973. Peripheral blood picture and histological findings of skin led to the diagnosis of malignant lymphoma (leukemic type). Intermittent chemotherapy kept white blood cell count less than 25,000/microliters for more than 9 years. In January, 1983, abnormal lymphocytes began to increase and reached 100,000/microliters or over in a few months. Surface marker study showed their phenotype as CD 4+5+8-, Leu 7+ and anti-ATLA antibody was positive in the patient, her son and her daughter. Intensive chemotherapy was ineffective and she died in August, 1983. Histological diagnosis of lymph-nodes on autopsy was malignant lymphoma (diffuse, small cell type). This case is considered unusual in both clinical course and surface phenotype of its leukemic cells.
报告了1例慢性成人T细胞白血病，急性发作期表面表型为CD 4+5+8-、Leu 7+。1973年12月，一名43岁女性因全身淋巴结肿大和皮疹前来我院就诊。外周血检查结果及皮肤组织学检查结果确诊为恶性淋巴瘤（白血病型）。间歇性化疗使白细胞计数在9年多的时间里维持在每微升25,000以下。1983年1月，异常淋巴细胞开始增多，几个月内达到每微升100,000或更高。表面标志物研究显示其表型为CD 4+5+8-、Leu 7+，该患者及其儿子和女儿的抗成人T细胞白血病抗体均为阳性。强化化疗无效，患者于1983年8月死亡。尸检时淋巴结的组织学诊断为恶性淋巴瘤（弥漫性小细胞型）。该病例在临床病程及其白血病细胞的表面表型方面均被认为不寻常。
