Koike M, Iida N, Wakabayashi Y, Ishiyama T, Uehara N, Shimizu K, Hirose S
Rinsho Ketsueki. 1989 Mar;30(3):404-7.
A 53-year-old woman born in Kamo village of Shizuoka prefecture was admitted to Juntendo Izunagaoka hospital complaining cough and appetite loss. On physical examinations, general lymphadenopathy and hepatosplenomegaly were recognized. And also dry rales and wet rales were heard in the bilateral lungs. On hematological examinations, leukocytes has counted 74,900/microliters, of which 61% atypical lymphocytes, and there were HTLV-I infection and positive anti-ATLA antibody. By the above results, she was diagnosed as adult T cell leukemia (ATL). T cell subset analysis was (CD4-, CD8-, CD3-), which is rare in ATL. Three months after the admission, she was died of disturbances of respiratory function in spite of VEPA therapy. Surface marker changed from CD3- to CD3+ in the course. To illuminate this mechanism will be a key step for the future study.
一名出生于静冈县加茂村的53岁女性因咳嗽和食欲减退入住顺天堂伊豆长冈医院。体格检查发现全身淋巴结肿大和肝脾肿大。双肺还可闻及干啰音和湿啰音。血液学检查显示白细胞计数为74,900/微升，其中61%为非典型淋巴细胞，存在HTLV-I感染且抗ATLA抗体呈阳性。根据上述结果，她被诊断为成人T细胞白血病（ATL）。T细胞亚群分析结果为（CD4-、CD8-、CD3-），这在ATL中较为罕见。入院三个月后，尽管接受了VEPA治疗，她仍死于呼吸功能障碍。病程中表面标志物从CD3-变为CD3+。阐明这一机制将是未来研究的关键一步。
