调控 RNA 的兴起。

The rise of regulatory RNA.

机构信息

School of Biotechnology and Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia; and Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.

Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia; the School of Biotechnology and Biomedical Sciences, and St. Vincent's Clinical School, University of New South Wales, Sydney, NSW 2052, Australia.

出版信息

Nat Rev Genet. 2014 Jun;15(6):423-37. doi: 10.1038/nrg3722. Epub 2014 Apr 29.

DOI:10.1038/nrg3722

PMID:24776770

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4314111/

Abstract

Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression, which is increasingly elaborate in complex organisms. Regulatory RNA seems to operate at many levels; in particular, it plays an important part in the epigenetic processes that control differentiation and development. These discoveries suggest a central role for RNA in human evolution and ontogeny. Here, we review the emergence of the previously unsuspected world of regulatory RNA from a historical perspective.

摘要

在过去的十年中，发现预示着分子生物学的范式转变。有证据表明，RNA 不仅作为 DNA 和蛋白质之间的信使起作用，而且还参与基因组组织和基因表达的调控，而在复杂生物中这种调控变得越来越精细。调节 RNA 似乎在多个层面上发挥作用；特别是，它在控制分化和发育的表观遗传过程中起着重要作用。这些发现表明 RNA 在人类进化和个体发生中起着核心作用。在这里，我们从历史的角度回顾了以前未被察觉的调节 RNA 世界的出现。