有证据表明鸡的CR1元件代表了一个反转录转座子的新家族。
Evidence that chicken CR1 elements represent a novel family of retroposons.
作者信息
Silva R, Burch J B
机构信息
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
出版信息
Mol Cell Biol. 1989 Aug;9(8):3563-6. doi: 10.1128/mcb.9.8.3563-3566.1989.
Abstract
We report the first precise delineation of a chicken CR1 element and show that it is flanked by a 6-base-pair target site duplication that occurred when this repetitive element transposed. The 3' end of this CR1 element is defined by an 8-base-pair imperfect direct repeat, and we infer that this sequence represents the 3' end of all intact CR1 elements. In contrast, the 5' ends are not unique, and we argue that this variation existed at the time each element transposed. We also provide evidence that CR1 elements transposed into preferred target sites. CR1 elements therefore appear to represent a novel class of passive retroposons.
摘要
我们报告了鸡CR1元件的首次精确描绘，并表明其两侧是该重复元件转座时发生的6个碱基对的靶位点重复序列。该CR1元件的3'端由一个8个碱基对的不完全直接重复序列定义，我们推断该序列代表所有完整CR1元件的3'端。相比之下，5'端并不唯一，我们认为这种变异在每个元件转座时就已存在。我们还提供了证据表明CR1元件转座到了偏好的靶位点。因此，CR1元件似乎代表了一类新型的被动反转录转座子。
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