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鸡卵黄生成素基因下游CR1家族的一个新的重复元件。

A new repetitive element of the CR1 family downstream of the chicken vitellogenin gene.

作者信息

van het Schip F, Samallo J, Meijlink F, Gruber M, AB G

出版信息

Nucleic Acids Res. 1987 May 26;15(10):4193-202. doi: 10.1093/nar/15.10.4193.

DOI:10.1093/nar/15.10.4193
PMID:3035488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC340841/
Abstract

We have analyzed a repetitive DNA sequence found in the 3'-flanking region of the chicken vitellogenin gene. By its sequence, the repetitive DNA has been identified as a hitherto unreported member of the chicken CR1 family of repetitive elements. The CR1 sequence displays the structural characteristics of a long terminal repeat located at the 3' end of an avian retrovirus. The CR1 element lies 2.2 kb downstream of the vitellogenin gene and 'points' away from the gene rather than toward it. In this respect, this element differs from other CR1 repeats. The CR1 element is embedded in a region showing changes in chromatin structure implying a potential role for this sequence in determining the structural state of the local chromatin.

摘要

我们分析了在鸡卵黄生成素基因3'侧翼区域发现的一段重复DNA序列。根据其序列，该重复DNA已被鉴定为鸡CR1重复元件家族中一个迄今未报道的成员。CR1序列显示出位于禽逆转录病毒3'端的长末端重复序列的结构特征。CR1元件位于卵黄生成素基因下游2.2 kb处，且“指向”远离该基因而非朝向它。在这方面，该元件不同于其他CR1重复序列。CR1元件嵌入在一个显示染色质结构变化的区域，这意味着该序列在决定局部染色质的结构状态方面可能发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e6/340841/5891f16107ee/nar00254-0256-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e6/340841/5891f16107ee/nar00254-0256-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e6/340841/5891f16107ee/nar00254-0256-a.jpg

相似文献

1
A new repetitive element of the CR1 family downstream of the chicken vitellogenin gene.鸡卵黄生成素基因下游CR1家族的一个新的重复元件。
Nucleic Acids Res. 1987 May 26;15(10):4193-202. doi: 10.1093/nar/15.10.4193.
2
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Evidence that chicken CR1 elements represent a novel family of retroposons.有证据表明鸡的CR1元件代表了一个反转录转座子的新家族。
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Analysis of a CR1 (chicken repeat) sequence flanking the 5' end of the gene encoding alpha-skeletal actin.对编码α-骨骼肌动蛋白基因5'端侧翼的CR1（鸡重复序列）序列的分析。
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引用本文的文献

1
Organization, sequence and nuclease hypersensitivity of repetitive elements flanking the chicken apoVLDLII gene: extended sequence similarity to elements flanking the chicken vitellogenin gene.鸡载脂蛋白VLDLII基因侧翼重复元件的组织、序列及核酸酶超敏感性：与鸡卵黄蛋白原基因侧翼元件的序列相似性扩展
Nucleic Acids Res. 1988 Jan 11;16(1):97-113. doi: 10.1093/nar/16.1.97.
2
The major and minor chicken vitellogenin genes are each adjacent to partially deleted pseudogene copies of the other.鸡的主要和次要卵黄蛋白原基因彼此相邻，且各自与对方部分缺失的假基因拷贝相邻。
Mol Cell Biol. 1989 Aug;9(8):3557-62. doi: 10.1128/mcb.9.8.3557-3562.1989.
3

本文引用的文献

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A chicken middle-repetitive DNA sequence which shares homology with mammalian ubiquitous repeats.一种与哺乳动物普遍存在的重复序列具有同源性的鸡中间重复DNA序列。
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Translation in vivo and in vitro of mRNAs coding for vitellogenin, serum albumin and very-low-density lipoprotein II from chicken liver. A difference in translational efficiency.鸡肝中编码卵黄蛋白原、血清白蛋白和极低密度脂蛋白II的mRNA的体内和体外翻译。翻译效率的差异。
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Transcriptional analysis of interspersed repetitive polymerase III transcription units in human DNA.
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鸡卵黄生成素基因3'端多态性的特征分析
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4
Evidence that chicken CR1 elements represent a novel family of retroposons.有证据表明鸡的CR1元件代表了一个反转录转座子的新家族。
Mol Cell Biol. 1989 Aug;9(8):3563-6. doi: 10.1128/mcb.9.8.3563-3566.1989.
5
Chromatin studies reveal that an ERE is located far upstream of a vitellogenin gene and that a distal tissue-specific hypersensitive site is conserved for two coordinately regulated vitellogenin genes.染色质研究表明，雌激素反应元件位于卵黄蛋白原基因的上游远处，并且两个协同调节的卵黄蛋白原基因存在一个保守的远端组织特异性超敏位点。
Nucleic Acids Res. 1990 Jul 25;18(14):4157-65. doi: 10.1093/nar/18.14.4157.
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Sequence conservation in avian CR1: an interspersed repetitive DNA family evolving under functional constraints.鸟类CR1中的序列保守性：一个在功能限制下进化的散布重复DNA家族。
Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5814-8. doi: 10.1073/pnas.88.13.5814.
人类DNA中散布的重复聚合酶III转录单位的转录分析。
Nucleic Acids Res. 1981 Mar 11;9(5):1171-89. doi: 10.1093/nar/9.5.1171.
4
Repetitive sequences in eukaryotic DNA and their expression.真核生物DNA中的重复序列及其表达。
Annu Rev Biochem. 1982;51:813-44. doi: 10.1146/annurev.bi.51.070182.004121.
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Coordinate regulation of two estrogen-dependent genes in avian liver.鸟类肝脏中两个雌激素依赖性基因的协同调控
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4474-8. doi: 10.1073/pnas.77.8.4474.
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Independent developmental programs for two estrogen-regulated genes.两个雌激素调节基因的独立发育程序。
Science. 1984 Aug 10;225(4662):639-41. doi: 10.1126/science.6740331.
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Genomic structure and possible retroviral origin of the chicken CR1 repetitive DNA sequence family.鸡CR1重复DNA序列家族的基因组结构及可能的逆转录病毒起源
Proc Natl Acad Sci U S A. 1984 Nov;81(21):6667-71. doi: 10.1073/pnas.81.21.6667.
8
Characterization of deoxyribonucleic acid sequences at the 5' and 3' borders of the 100 kilobase pair ovalbumin gene domain.100千碱基对卵清蛋白基因结构域5'和3'边界处脱氧核糖核酸序列的特征分析
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Isolation and characterization of genomic clones covering the chicken vitellogenin gene.覆盖鸡卵黄蛋白原基因的基因组克隆的分离与鉴定。
Nucleic Acids Res. 1981 Jul 24;9(14):3271-86. doi: 10.1093/nar/9.14.3271.
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Presence of a highly repetitive and widely dispersed DNA sequence in the human genome.人类基因组中存在高度重复且广泛分布的DNA序列。
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