Inouye Kimberly Ann S, Bisch Frederick C, Elsalanty Mohammed E, Zakhary Ibrahim, Khashaba Rania M, Borke James L
*Graduate Student, Department of Oral Biology, Georgia Regents University, Augusta, GA. †Resident, US Army Advanced Education Program in Periodontics, Fort Gordon, Augusta, GA. ‡Colonel, US Army Advanced Education Program in Periodontics, Fort Gordon, Augusta, GA. §Professor, Department of Oral Biology, Georgia Regents University, Augusta, GA. ‖Research Associate, Department of Oral Biology, Georgia Regents University, Augusta GA. ¶Assistant Professor, Department of Biomaterials, Misr International University, Cairo, Egypt. #Professor, Department of Oral Biology, Georgia Regents University, Augusta, GA; Professor, College of Dental Medicine, Western University of Health Sciences, Pomona, CA.
Implant Dent. 2014 Jun;23(3):319-27. doi: 10.1097/ID.0000000000000069.
To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing.
Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 × 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD).
At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls.
Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration.
研究高血糖和二甲双胍（一种常用的双胍类抗糖尿病药物）对种植体周围愈合的影响。
将36只雄性大鼠分为3组：（1）非糖尿病Wistar-Kyoto大鼠（对照组），（2）Goto-Kakizaki（GK）自发性糖尿病大鼠（GK组），（3）GK大鼠在饮水中给予二甲双胍（每天100mg/kg体重），持续4周（GK + Met组）。拔除右上颌第一磨牙，让拔牙部位愈合1个月。将钛种植体（1×3mm）植入愈合的拔牙部位。在第1周和第4周，通过微型计算机断层扫描分析每组6只大鼠的骨/种植体接触率、骨体积百分比、骨小梁数量和骨密度。还分析血液中的葡萄糖、糖化血红蛋白和吡啶啉（PYD）。
在第1周，GK-Met大鼠的血糖水平较高，所有骨参数与GK大鼠相似（骨参数低于对照组，PYD高于对照组）。在第4周，GK-Met大鼠的血糖水平和所有参数与对照组相似。
高血糖的GK 2型糖尿病大鼠在给予二甲双胍后，血糖水平改善，口腔种植体周围的伤口愈合情况良好。
