Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II.
作者信息
Sopta M, Burton Z F, Greenblatt J
机构信息
Department of Medical Genetics, University of Toronto, Ontario, Canada.
出版信息
Nature. 1989 Oct 5;341(6241):410-4. doi: 10.1038/341410a0.
DOI:10.1038/341410a0
PMID:2477704
Abstract
RAP30/74 is a heteromeric general transcription initiation factor which binds to RNA polymerase II. Here we report that preparations of RAP30/74 contain an ATP-dependent DNA helicase whose probable function is to melt the DNA at transcriptional start sites. The sequence of the RAP30 subunit of RAP30/74 indicates that RAP30 may be distantly related to bacterial sigma factors.
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