Moghari Mehdi H, Komarlu Rukmini, Annese David, Geva Tal, Powell Andrew J
Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Magn Reson Med. 2015 Apr;73(4):1555-61. doi: 10.1002/mrm.25275. Epub 2014 Apr 28.
To develop and validate a respiratory motion compensation method for free-breathing cardiac cine imaging.
A free-breathing navigator-gated cine steady-state free precession acquisition (Cine-Nav) was developed which preserves the equilibrium state of the net magnetization vector, maintains the high spatial and temporal resolutions of standard breath-hold (BH) acquisition, and images entire cardiac cycle. Cine image data is accepted only from cardiac cycles occurring entirely during end-expiration. Prospective validation was performed in 10 patients by obtaining in each three complete ventricular image stacks with different respiratory motion compensation approaches: (1) BH, (2) free-breathing with 3 signal averages (3AVG), and (3) free-breathing with Cine-Nav.
The subjective image quality score (1 = worst, 4 = best) for Cine-Nav (3.8 ± 0.4) was significantly better than for 3AVG (2.2 ± 0.5, P = 0.002), and similar to BH (4.0 ± 0.0, P = 0.13). The blood-to-myocardium contrast ratio for Cine-Nav (6.3 ± 1.5) was similar to BH (5.9 ± 1.6, P = 0.52) and to 3AVG (5.6 ± 2.5, P = 0.43). There were no significant differences between Cine-Nav and BH for the ventricular volumes and mass. In contrast, there were significant differences between 3AVG and BH in all of these measurements but right ventricular mass.
Free-breathing cine imaging with Cine-Nav yielded comparable image quality and ventricular measurements to BH, and was superior to 3AVG.
开发并验证一种用于自由呼吸心脏电影成像的呼吸运动补偿方法。
开发了一种自由呼吸导航门控电影稳态自由进动采集（Cine-Nav）方法，该方法能保持净磁化矢量的平衡状态，维持标准屏气（BH）采集的高空间和时间分辨率，并对整个心动周期进行成像。仅接受完全在呼气末发生的心动周期的电影图像数据。通过对10名患者进行前瞻性验证，对每位患者分别采用三种不同的呼吸运动补偿方法获取三个完整的心室图像堆栈：（1）屏气，（2）自由呼吸并进行3次信号平均（3AVG），（3）自由呼吸并采用Cine-Nav。
Cine-Nav的主观图像质量评分（1 =最差，4 =最佳）为（3.8±0.4），显著优于3AVG（2.2±0.5，P = 0.002），且与屏气（4.0±0.0，P = 0.13）相似。Cine-Nav的血-心肌对比度比值为（6.3±1.5），与屏气（5.9±1.6，P = 0.52）和3AVG（5.6±2.5，P = 0.43）相似。Cine-Nav与屏气在心室容积和质量方面无显著差异。相比之下，3AVG与屏气在所有这些测量指标上（除右心室质量外）均存在显著差异。
采用Cine-Nav的自由呼吸电影成像在图像质量和心室测量方面与屏气相当，且优于3AVG。
