Oshima Takashi, Yoshihara Kazue, Aoyama Toru, Hasegawa Shinich, Sato Tsutomu, Yamamoto Naoto, Akito Nozaki, Shiozawa Manabu, Yoshikawa Takaki, Numata Kazushi, Rino Yasushi, Kunisaki Chikara, Tanaka Katsuaki, Akaike Makoto, Imada Toshio, Masuda Munetaka
Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafunecho, Minami-ku, Yokohama, Kanagawa 232-0024, Japan.
Anticancer Res. 2014 May;34(5):2303-9.
Inhibin-βA (INHBA), a ligand belonging to the transforming growth factor-β superfamily, is associated with cell proliferation in cancer. We studied the relations of INHBA gene expression to clinicopathological factors and outcomes in 168 patients with gastric cancer who underwent curative surgery. Relative INHBA gene expression was measured in surgical specimens of cancer tissue and adjacent normal mucosa by quantitative real-time, reverse-transcription polymerase chain reaction. INHBA expression levels were significantly higher in cancer tissue than in adjacent normal mucosa and were related to TNM stage and venous invasion. High INHBA gene expression was associated with significantly poorer 5-year overall survival than was low expression. On multivariate analysis, INHBA gene expression was an independent prognostic factor. Overexpression of the INHBA gene is considered a useful independent predictor of outcomes in patients with gastric cancer after curative surgery.
抑制素-βA（INHBA）是一种属于转化生长因子-β超家族的配体，与癌症中的细胞增殖有关。我们研究了168例行根治性手术的胃癌患者中INHBA基因表达与临床病理因素及预后的关系。通过定量实时逆转录聚合酶链反应测定癌组织和癌旁正常黏膜手术标本中的相对INHBA基因表达。癌组织中INHBA表达水平显著高于癌旁正常黏膜，且与TNM分期和静脉侵犯有关。INHBA基因高表达与5年总生存率显著低于低表达相关。多因素分析显示，INHBA基因表达是一个独立的预后因素。INHBA基因的过表达被认为是胃癌根治术后患者预后的一个有用的独立预测指标。
