Gripp Daniel Andrade, do Souto Antonio Aversa, Gonsales Douglas, Christiani Marcio de Miranda Chaves, Nogueira Janio, Lopes Helio Ferreira, Torres Yasmine Coura
Department of Neurosurgery, National Institute of Cancer, INCA, Centro, Rio de Janeiro, Brazil.
Surg Neurol Int. 2014 Feb 17;5:18. doi: 10.4103/2152-7806.127257. eCollection 2014.
Chordomas are rare slowly growing tumors that originate from remnants of the notochord. They have a malignant local behavior, causing symptoms due to bone infiltration and compression of neurovascular structures. Only a few cases of brain tumors associated with pathological laughter have been reported in the literature.
We report a case of a 42-year-old male patient with this atypical clinical presentation treated at our institution, and discuss the concerning literature.
Although being a very rare presentation of chordomas, pathological laughter is usually expected to improve after brain stem decompression.