巨大斜坡脊索瘤导致病理性发笑。
Giant clival chordoma causing pathological laughter.
作者信息
Gripp Daniel Andrade, do Souto Antonio Aversa, Gonsales Douglas, Christiani Marcio de Miranda Chaves, Nogueira Janio, Lopes Helio Ferreira, Torres Yasmine Coura
机构信息
Department of Neurosurgery, National Institute of Cancer, INCA, Centro, Rio de Janeiro, Brazil.
出版信息
Surg Neurol Int. 2014 Feb 17;5:18. doi: 10.4103/2152-7806.127257. eCollection 2014.
BACKGROUND
Chordomas are rare slowly growing tumors that originate from remnants of the notochord. They have a malignant local behavior, causing symptoms due to bone infiltration and compression of neurovascular structures. Only a few cases of brain tumors associated with pathological laughter have been reported in the literature.
CASE DESCRIPTION
We report a case of a 42-year-old male patient with this atypical clinical presentation treated at our institution, and discuss the concerning literature.
CONCLUSION
Although being a very rare presentation of chordomas, pathological laughter is usually expected to improve after brain stem decompression.
背景
脊索瘤是一种罕见的生长缓慢的肿瘤，起源于脊索的残余部分。它们具有恶性的局部行为，由于骨浸润和神经血管结构受压而引起症状。文献中仅报道了少数与病理性发笑相关的脑肿瘤病例。
病例描述
我们报告了一例在我院接受治疗的具有这种非典型临床表现的42岁男性患者，并讨论相关文献。
结论
尽管病理性发笑是脊索瘤非常罕见的表现，但通常预期在脑干减压后会有所改善。
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